2013 Fiscal Year Final Research Report
Growth control of liver cancer cells by targeting viral-host chimeric transcript resulted from hepatitis B virus integration
| Project/Area Number |
23590984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MINAMI Masahito 京都府立医科大学, 医学(系)研究科(研究院), 講師 (60326220)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肝癌 / B型肝炎ウイルス |
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| Research Abstract |
Hepatitis B virus (HBV) has been known to be integrated in the host genome in hepatocellular carcinoma. Here, we have clearly demonstrated that HBV integration occurs in chronic hepatitis tissues. These events can cause insertional mutagenesis in integrated genes and influence the transcription of the affected genes. We also found that HBV integration has favorite sites, such as chromosome 3 and common fragile sites, demonstrating that HBV integration is not a random event, but may result in some selection probably by affected genes. These findings suggest that HBV integration causes host genome mutation at early stages of chronic HBV infection preceding hepatocellular carcinoma and may be associated with persisitence and carcinogenesis of affected cells.
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[Journal Article] Efficacy and safety of sorafenib in very elderly patients aged 80 years and older with advanced hepatocellular carcinoma2014
Author(s)
Jo M, Yasui K, Kirishima T, Shima T, Niimi T, Katayama T, Mori T, Funaki J, Sumida Y, Fujii H, Takami S, Kimura H, Mitsumoto Y, Minami M, Yamaguchi K, Yoshinami N, Mizuno M, Sendo R, Tanaka S, Shintani H, Kagawa K, Okanoue T, Itoh Y
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Journal Title
Hepatol Res
Volume: (Epub ahead of print)
DOI
Peer Reviewed
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[Journal Article] Factors associated with the overall survival of elderly patients with hepatocellular carcinoma2012
Author(s)
Fujii H, Itoh Y, Ohnishi N, Sakamoto M, Ohkawara T, Sawa Y, Nishida K, Ohkawara Y, Yamaguchi K, Minami M, Okanoue T
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Journal Title
World J Gastroenterol
Volume: 18(16)
Pages: 1926-32
DOI
Peer Reviewed
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[Journal Article] High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells2011
Author(s)
Yokomizo C, Yamaguchi K, Itoh Y, Nishimura T, Umemura A, Minami M, Yasui K, Mitsuyoshi H, Fujii H, Tochiki N, Nakajima T, Okanoue T, Yoshikawa T
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Journal Title
Cancer Lett
Volume: 310(2)(Epub 2011 Jul 1)
Pages: 140-7
DOI
Peer Reviewed
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[Journal Article] Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma2011
Author(s)
Jo M, Nishikawa T, Nakajima T, Okada Y, Yamaguchi K, Mitsuyoshi H, Yasui K, Minami M, Iwai M, Kagawa K, Itoh Y, Yoshikawa T
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Journal Title
J Gastroenterol
Volume: 46(6)(Epub 2011 Mar 31)
Pages: 809-21
DOI
Peer Reviewed
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