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2013 Fiscal Year Final Research Report

Pathogenesis of hepatitis B virus in hepatocyte, undetectable in peripheral blood

Research Project

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Project/Area Number 23590985
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionOsaka City University

Principal Investigator

TAMORI Akihiro  大阪市立大学, 医学(系)研究科(研究院), 准教授 (30291595)

Co-Investigator(Kenkyū-buntansha) ENOMOTO Masaru  大阪市立大学, 大学院医学研究科, 准教授 (20423874)
MURAKAMI Yoshiki  大阪市立大学, 大学院医学研究科, 准教授 (00397556)
Project Period (FY) 2011 – 2013
KeywordsB型肝炎ウイルス / 再活性化 / 長期予後
Research Abstract

To elucidate the clinical characteristics of hepatitis B virus reactivation (HBV-R), we performed a prospective long-term study of patients who receive immunosuppressive or cytotoxic therapy. We enrolled 229 patients with anti-HBc. HBV DNA levels were measured every month to 3 months by a real-time PCR method. The mean observation period was 24 months (range: 2-61 months). Entecavir was administered to all of 20 patients with more than 2.1 log/ml of HBV DNA at the enrollment. In HBsAg-negative patients, HBV was reactivated in 3/30 (10%) ML patients treated with rituximab combination therapy, and 5/19 (26%) patients with HSCT. In RA patients, HBV reactivation occurred in 3/88 (3%) patients. Entecavir inhibited HBV amplification and prevented HBV-associated hepatic failure in patients with HBV reactivation. Mutations in the 'a' determinant region with amino acid replacement were detected in 4 of the 8 patients with HBV-R.

  • Research Products

    (21 results)

All 2014 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (10 results) Book (1 results) Remarks (1 results)

  • [Journal Article] A prospective long-term study of hepatitis B virus reactivation in patients with hematologic malignancy2014

    • Author(s)
      Tamori A, Hino M, Kawamura E, Fujii H, Uchida-Kobayashi S, Morikawa H, Nakamae H, Enomoto M, Murakami Y, Kawada N.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia2014

    • Author(s)
      Nishida N, Sawai H, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Tamori A, Orito E, Hiasa Y, Honda M, Kaneko S, Kawashima M, Tokunaga K, Mizokami M et al.
    • Journal Title

      PLoS One

      Volume: 9 Pages: e86449

    • DOI

      10.1371/journal.pone.0086449

    • Peer Reviewed
  • [Journal Article] Combination therapy with a nucleos(t)ide analogue and interferon for chronic hepatitis B : simultaneous or sequential2013

    • Author(s)
      Enomoto M, Tamori A, Nishiguchi S, Kawada N.
    • Journal Title

      J Gastroenterol

      Volume: 48 Pages: 999-1005

    • DOI

      10.1007/s00535-012-0742-5

    • Peer Reviewed
  • [Journal Article] HLA class II associated with outcomes of hepatitis B and C infections2013

    • Author(s)
      Tamori A, Kawada N.
    • Journal Title

      World J Gastroenterol

      Volume: 19 Pages: 5395-401

    • DOI

      10.3748/wjg.v19.i33.5395

    • Peer Reviewed
  • [Journal Article] Entecavir and interferon-αsequential therapy in Japanese patients with hepatitis B e antigen-positive chronic hepatitis B2013

    • Author(s)
      Enomoto M, Nishiguchi S, Tamori A, Kobayashi S, Sakaguchi H, Shiomi S, Kim SR, Enomoto H, Saito M, Imanishi H, Kawada N.
    • Journal Title

      J Gastroenterol

      Volume: 48 Pages: 397-404

    • DOI

      10.1007/s00535-012-0645-5

    • Peer Reviewed
  • [Journal Article] Anti-hepatitis B virus therapy : To stop, or not to stop : Has the question been solved?2012

    • Author(s)
      Kozuka R, Enomoto M, Morikawa H, Tamori A, Kawada N.
    • Journal Title

      Hepatol Res.

      Volume: 42 Pages: 946-7

    • DOI

      10.1111/j.1872-034X.2012.01001.x

    • Peer Reviewed
  • [Journal Article] Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean2012

    • Author(s)
      Nishida N, Sawai H, Matsuura K, Kaneko S, Orito E, Itoh Y, Mita E, Tamori A, Tanaka Y, Tokunaga K, Mizokami M et al.
    • Journal Title

      PLoS One

      Volume: 76 Pages: e39175

    • DOI

      10.1371/journal.pone.0039175

    • Peer Reviewed
  • [Journal Article] Significant background rates of HBV and HCV infections in patients and risks of blood transfusion from donors with low anti-HBc titres or high anti-HBc titres with high anti-HBs titres in Japan : a prospective, individual NAT study of transfusion-transmitted HBV, HCV and HIV infections2012

    • Author(s)
      Tani Y, Aso H, Matsukura H, Tadokoro K, Tamori A, Nishiguchi S, Yoshizawa H, Shibata H.
    • Journal Title

      Vox Sang.

      Volume: 102 Pages: 285-93

    • DOI

      10.1111/j.1423-0410.2011.01561.x

    • Peer Reviewed
  • [Journal Article] Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy : evaluation of both HBsAg-positive and HBsAg-negative cohorts2011

    • Author(s)
      Tamori A, Koike T, Goto H, Wakitani S, Tada M, Morikawa H, Enomoto M, Inaba M, Nakatani T, Hino M, Kawada N.
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 555-64

    • DOI

      10.1007/s00535-010-0367-5

    • Peer Reviewed
  • [Presentation] HBV再活性化における宿主因子とウイルス因子に関する検討2014

    • Author(s)
      田守昭博他
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29
  • [Presentation] Clinical characteristics of hepatitis B virus reactivation in prospective long-term study for patients with hematologic malignancy2014

    • Author(s)
      Tamori A, et al.
    • Organizer
      第49回ヨーロッパ肝臓学会
    • Place of Presentation
      ロンドン
    • Year and Date
      2014-04-11
  • [Presentation] 前向き登録例の長期経過からみたHBV再活性対策の現状2013

    • Author(s)
      田守昭博他
    • Organizer
      第17回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-09
  • [Presentation] 全数調査から見た輸血後B型肝炎ウイルス陽転例の解析—HBV再活性化の可能性—2013

    • Author(s)
      田守昭博他
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-07
  • [Presentation] 長期観察によるHBV再活性化頻度と治療介入例の予後2013

    • Author(s)
      田守昭博他
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-03-22
  • [Presentation] B型肝炎の最新情報2012

    • Author(s)
      田守昭博
    • Organizer
      第56回日本輸血・細胞治療学会近畿支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-17
  • [Presentation] Prospective, individual NAT study of transfusion- transmitted HBV, HCV and HIV infections; JRC NAT Screening Research2012

    • Author(s)
      Tamori A, et al.
    • Organizer
      第63回アメリカ肝臓病学会
    • Place of Presentation
      ボストン
    • Year and Date
      2012-11-10
  • [Presentation] 前向き研究からみたB型肝炎ウイルス再活性化の頻度とHBs抗体価の推移2012

    • Author(s)
      田守昭博他
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
  • [Presentation] B型肝炎ウイルス再活性化の頻度とウイルス変異の臨床的意義2011

    • Author(s)
      田守昭博他
    • Organizer
      第39回日本肝臓学会西部会
    • Place of Presentation
      岡山
    • Year and Date
      2011-12-09
  • [Presentation] Prospective study of reactivation of hepatitis B virus in patients who received immunosuppressive therapy or cytotoxic therapy : Evaluation of both HBsAg- positive and - negative cohorts2011

    • Author(s)
      Tamori A, et al.
    • Organizer
      第62回アメリカ肝臓病学会
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2011-11-06
  • [Book] B型肝炎再活性化の現状と対策2013

    • Author(s)
      田守昭博他
    • Total Pages
      148
    • Publisher
      最新医学社
  • [Remarks]

    • URL

      http://www.med.osaka-cu.ac.jp/syoukaki/hepatology/research/ronbun.shtml

URL: 

Published: 2015-07-16  

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