2013 Fiscal Year Final Research Report
Pathogenesis of hepatitis B virus in hepatocyte, undetectable in peripheral blood
| Project/Area Number |
23590985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
TAMORI Akihiro 大阪市立大学, 医学(系)研究科(研究院), 准教授 (30291595)
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| Co-Investigator(Kenkyū-buntansha) |
ENOMOTO Masaru 大阪市立大学, 大学院医学研究科, 准教授 (20423874)
MURAKAMI Yoshiki 大阪市立大学, 大学院医学研究科, 准教授 (00397556)
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| Project Period (FY) |
2011 – 2013
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| Keywords | B型肝炎ウイルス / 再活性化 / 長期予後 |
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| Research Abstract |
To elucidate the clinical characteristics of hepatitis B virus reactivation (HBV-R), we performed a prospective long-term study of patients who receive immunosuppressive or cytotoxic therapy. We enrolled 229 patients with anti-HBc. HBV DNA levels were measured every month to 3 months by a real-time PCR method. The mean observation period was 24 months (range: 2-61 months). Entecavir was administered to all of 20 patients with more than 2.1 log/ml of HBV DNA at the enrollment. In HBsAg-negative patients, HBV was reactivated in 3/30 (10%) ML patients treated with rituximab combination therapy, and 5/19 (26%) patients with HSCT. In RA patients, HBV reactivation occurred in 3/88 (3%) patients. Entecavir inhibited HBV amplification and prevented HBV-associated hepatic failure in patients with HBV reactivation. Mutations in the 'a' determinant region with amino acid replacement were detected in 4 of the 8 patients with HBV-R.
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Research Products
(21 results)
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[Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia2014
Author(s)
Nishida N, Sawai H, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Tamori A, Orito E, Hiasa Y, Honda M, Kaneko S, Kawashima M, Tokunaga K, Mizokami M et al.
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Journal Title
PLoS One
Volume: 9
Pages: e86449
DOI
Peer Reviewed
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[Journal Article] Entecavir and interferon-αsequential therapy in Japanese patients with hepatitis B e antigen-positive chronic hepatitis B2013
Author(s)
Enomoto M, Nishiguchi S, Tamori A, Kobayashi S, Sakaguchi H, Shiomi S, Kim SR, Enomoto H, Saito M, Imanishi H, Kawada N.
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Journal Title
J Gastroenterol
Volume: 48
Pages: 397-404
DOI
Peer Reviewed
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[Journal Article] Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean2012
Author(s)
Nishida N, Sawai H, Matsuura K, Kaneko S, Orito E, Itoh Y, Mita E, Tamori A, Tanaka Y, Tokunaga K, Mizokami M et al.
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Journal Title
PLoS One
Volume: 76
Pages: e39175
DOI
Peer Reviewed
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[Journal Article] Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy : evaluation of both HBsAg-positive and HBsAg-negative cohorts2011
Author(s)
Tamori A, Koike T, Goto H, Wakitani S, Tada M, Morikawa H, Enomoto M, Inaba M, Nakatani T, Hino M, Kawada N.
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Journal Title
J Gastroenterol
Volume: 46
Pages: 555-64
DOI
Peer Reviewed
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