2013 Fiscal Year Final Research Report
Establishment of new therapy for chronic liver diseases progression
Project/Area Number |
23590986
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Nara Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Ryuuichi 奈良県立医科大学, 医学部, 助教 (30423908)
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Project Period (FY) |
2011 – 2013
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Keywords | 肝硬変 / 肝癌 / 血管新生 |
Research Abstract |
During the period of this grant, we revealed many new findings about the usefulness of the combined cocktail therapy of clinical available agents in patients with chronic liver diseases. Even at clinical comparable low doses of these agents, we observed significant inhibitory effects on the liver fibrosis development, hepatocarcinogenesis, and the growth of hepatocellular carcinoma (HCC). We mainly focused on renin-angiotensin system (RAS) in the chronic liver diseases, and found that angiotensin-II (AT-II), aldosterone (Ald), and renin play important roles in the respective processes. Several different combination cocktail treatments also exerted marked inhibitory effects even at clinically comparable low doses. Furthermore, not only in the animal studies, but also we revealed clinical usefulness with these agents. Collectively, our studies with this grant could contribute to the improvement of prognosis in patients with chronic liver diseases.
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[Journal Article] Direct renin inhibitor, aliskiren, attenuates the progression of non-alcoholic steatohepatitis in the rat model2013
Author(s)
Aihara Y, Yoshiji H, Noguchi R, Kaji K, Namisaki T, Shirai Y, Douhara A, Moriya K, Kawaratani H, Fukui H
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Journal Title
Hepatol Res
Volume: 43(11)
Pages: 1241-50
DOI
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[Journal Article] Branched-chain amino acids suppress the cumulative recurrence of hepatocellular carcinoma under conditions of insulin-resistance2013
Author(s)
Yoshiji H, Noguchi R, Namisaki T, Moriya K, Kitade M, Aihara Y, Douhara A, Yamao J, Fujimoto M, Toyohara M, Mitoro A, Sawai M, Yoshida M, Morioka C, Uejima M, Uemura M, Fukui H
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Journal Title
Oncology Reports
Volume: 30
Pages: 545-552
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[Journal Article] Dual blockade of angiotensin-IIand aldosterone suppresses the progression of a non-diabetic rat model of steatohepatitis2013
Author(s)
Noguchi R, Yoshiji H, Ikenaka Y, Kaji K, Aihara Y, Shirai Y, Namisaki T, Kitade M, Douhara A, Moriya K, Fukui H
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Journal Title
Hepatology Research
Volume: 43(7)
Pages: 765-774
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[Journal Article] Combination of branched-chain amino acid and angiotensin-converting enzyme inhibitor improves liver fibrosis progression in patients with cirrhosis2012
Author(s)
Yoshiji H, Noguchi R, Ikenaka Y, Kaji K, Aihara Y, Douhara A, Yamao J, Toyohara M, Mitoro A, Sawai M, Yoshida M, Morioka C, Fujimoto M, Uemura M, Fukui H
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Journal Title
Molecular Medicine Reports
Volume: 5
Pages: 539-544
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[Journal Article] Combination treatment of angiotensinIItypeIreceptor blocker and new oral iron chelator attenuates progression of nonalcoholic steatohepatitis in rats2011
Author(s)
Kaji K, Yoshiji H, Kitade M, Ikenaka Y, Noguchi R, Shirai Y, Aihara Y, Namisaki T, Yoshii J, Yanase K, Tsujimoto T, Kawaratani H, Fukui H
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Journal Title
Am J Physiol Gastrointest Liver Physiol
Volume: 300
Pages: 1094-1104
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[Journal Article] Soluble VEGF receptor-2 may be a predictive marker of anti-angiogenic therapy with clinically available safe agents2011
Author(s)
Yoshiji H, Noguchi R, Ikenaka Y, Kaji K, Shirai Y, Aihara Y, Yamao J, Toyohara M, Mitoro A, Sawai M, Yoshida M, Morioka C, Fujimoto M, Uemura M, Kawaratani H, Tsujimoto T, Fukui H
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Journal Title
Oncology Letters
Volume: 2
Pages: 69-73
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[Presentation] Combination of angiotensin-converting enzyme inhibitor and selective aldosterone blocker, suppresses the liver fibrosis carcinogenesis of nonalcoholic steatohepatitis in the rat2013
Author(s)
Noguchi R, Yoshiji H, Namisaki T, Moriya K, Kitade M, Aihara Y, Douhara A, Kawaratani H, Nishimura N, Fukui H
Organizer
International Society for Hepatic Sinusoidal Research
Place of Presentation
Osaka
Year and Date
2013-09-24
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