2013 Fiscal Year Final Research Report
Unraveling the role of Angptl2 in the pathogenesis of steatohepatitis and liver cancer
| Project/Area Number |
23591001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
TOMITA Kengo 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 講師 (50317129)
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| Co-Investigator(Kenkyū-buntansha) |
SEKI Shuji 防衛医科大学校, 医学教育部医学科専門課程, 教授 (80531392)
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| Co-Investigator(Renkei-kenkyūsha) |
OIKE Yuichi 熊本大学, 大学院, 教授 (90312321)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 非アルコール性脂肪肝炎 / 肝臓線維化 / 肝臓癌 / Angptl2 |
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| Research Abstract |
Angiopoietin-like protein 2 (Angptl2) is an adipocytokine, which induces chemotaxis of macrophages to adipose tissue, exaggerates adipose tissue inflammation, and aggravates insulin resistance and obesity. Nonalcoholic steatohepatitis (NASH) is thought to be a hepatic manifestation of metabolic syndrome. Therefore, Angptl2 may play an important role in the pathogenesis of NASH and NASH-related liver cancer. In the present study, we tried to unravel the role of Angptl2 in the progression of NASH and NASH-related liver cancer, using Angptl2-deficient mice and human liver samples in patients with NASH or liver cancer. We intend to promote necessary study and research for clinical application.
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