Clinical Significance of BAFF and APRIL in AIP

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591014
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: KUMAGI Teru 愛媛大学, 医学(系)研究科(研究院), 寄附講座准教授 (30594147)
• Project Period (FY): 2011 – 2013
• Keywords: 自己免疫性膵炎 / 膵癌 / BAFF / APRIL / 鑑別診断 / 治療効果判定

Research Abstract

Although high serum levels of B cell-activating factor (BAFF) are reported in patients with autoimmune pancreatitis (AIP) and some malignant diseases, its role in the pathogenesis remains unclear. In this study, we aimed to understand the role of BAFF in the pathogenesis of AIP and pancreatic cancer (PC). First, using serum and pancreatic tissues from patients with PC, and PC cell line, we showed that BAFF was elevated in patients with metastatic advanced PC and induced alterations in PC cells via regulation of EMT-related genes. Second, using serum and pancreatic tissues from patients with AIP, and mice with various features of AIP, we identified that overexpression of lymphotoxin (LT) beta specifically in acinar cells of mice caused features of AIP.

Research Products

• [Journal Article] Increased B cell-activating factor promotes tumor invasion and metastasis in human pancreatic cancer (2013)
  • Author(s): Koizumi M, Hiasa Y, Kumagi T, et al.
  • Journal Title: PLoS One Volume: Aug 6;8(8) Pages: e71367
  • Peer Reviewed
• [Journal Article] as the Ehime Pancreato-Cholangiology (EPOCH) Study Group. Improvement of long-term outcomes in pancreatic cancer and its associated factors within the gemcitabine era : A collaborative retrospective multi- center clinical review of 1,082 patients (2013)
  • Author(s): Kuroda T, Kumagi T, Yokota T, et al.
  • Journal Title: BMC Gastroenterology Volume: 13 Pages: 134
  • Peer Reviewed
• [Journal Article] 当科で経過をおえた膵癌stageIVb死亡症例における予後因子の検討 (2013)
  • Author(s): 畔元信明、熊木天児、黒田太良, 他
  • Journal Title: 愛媛医学 Volume: 32 Pages: 15-18
  • Peer Reviewed
• [Journal Article] LymphotoxinβReceptor Signaling Promotes Development of Autoimmune Pancreatitis (2012)
  • Author(s): Seleznik GM, Reding T, Kumagi T, et al.
  • Journal Title: Gastroenterology Volume: 143 Pages: 1361-74
  • Peer Reviewed
• [Presentation] 膵癌進展に及ぼすB細胞活性化因子(BAFF)の作用 (2013)
  • Author(s): 小泉光仁,日浅陽一,熊木天児,阿部雅則,松浦文三,恩地森一
  • Organizer: 第44回日本膵臓学会大会
  • Place of Presentation: 仙台
  • Year and Date: 20130725-26
• [Presentation] 新規化学療法時代における愛媛県膵癌診療の現状と展望 (2013)
  • Author(s): 熊木天児,黒田太良,横田智行,清家裕貴,西山麻里,今井祐輔,稲田暢,柴田直純,今峰聡,岡田眞一,小泉光仁,山西浩文,畔元信明,長谷部昌,田中良憲,達川はるか,宇都宮大貴,恩地森一,日浅陽一
  • Organizer: 第99回日本消化器病学会四国支部例会
  • Place of Presentation: 高知
  • Year and Date: 20130629-30
• [Presentation] Changes in the characteristics and prognosis of pancreatic cancer within the gemcitabine era and the issues facing elderly patients (2013)
  • Author(s): Kuroda T,Kumagi T,Yokota T,Seike H,Miyaike J,Nishiyama M,Imai Y,Tatsukawa H,Shibata N,Koizumi M,Yamanishi H,Azemoto N,Abe M,Matsuura B,Hiasa Y,Onji M.
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orlando,USA
  • Year and Date: 20130518-21
• [Presentation] Increased B cell-activating factor promotes epithelial- mesenchymal transition in human pancreatic cancer (2013)
  • Author(s): Koizumi M, Hiasa Y, Kumagi T, Yamanishi H, Azemoto N, Abe M, Ikeda Y, Matsuura B, Onji M.
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orlando,USA
  • Year and Date: 20130518-21
• [Presentation] 高齢者に対する膵癌診療の実態および問題点 (2013)
  • Author(s): 黒田太良,熊木天児,小泉光仁,畔元信明,山西浩文,恩地森一、横田智行、清家裕貴、長谷部昌、今井祐輔、田中良憲、稲田暢
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
  • Year and Date: 20130321-23
• [Presentation] 愛媛県消化器内科における膵癌診療の実態 (2012)
  • Author(s): 黒田太良,熊木天児,小泉光仁,畔元信明,山西浩文,恩地森一,横田智行,清家裕貴,上原貴秀,今井祐輔,達川はるか,宇都宮大貴,西山麻里,稲田暢,芝田直純,今峰聡,岡田眞一
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸
  • Year and Date: 20121010-13
• [Presentation] 当科における膵癌stageIVb患者の予後を規定する因子の検討 (2012)
  • Author(s): 畔元信明,熊木天児,山西浩文,黒田太良,小泉光仁,阿部雅則,松浦文三,日浅陽一,恩地森一
  • Organizer: 第43回日本膵臓学会大会
  • Place of Presentation: 山形
  • Year and Date: 20120628-29