2013 Fiscal Year Final Research Report
Development of the pancreatic cancer therapy by identification of EMT inducer by chemotherapy
| Project/Area Number |
23591016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
SHIMASAKI Takeo 金沢医科大学, 総合医学研究所, 講師 (50377420)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGAKI Yasuhito 金沢医科大学, 総合医学研究所, 准教授 (20232275)
TOMOSUGI Naohisa 金沢医科大学, 総合医学研究所, 教授 (80155580)
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| Co-Investigator(Renkei-kenkyūsha) |
MOTOO Yoshiharu 金沢医科大学, 医学部, 教授 (80210095)
MINAMOTO Toshinari 金沢大学, がん研究所, 教授 (50239323)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 化学療法 / EMT / ドラッグリポジショニング / 膵臓がん / GSK３β |
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| Research Abstract |
Pancreatic cancer is obstinate and results in a highly invasive and metastatic tumor phenotype that is a major obstacle to chemotherapy. We found that the pancreatic cancer cell lines exposed low concentration of gemcitabine triggered the cellular morphological change showing epithelial to mesenchymal transition (EMT) and up-regulated motility. These phenomenon are inhibited by GSK3beta inhibitor. We proposed a new strategy of inhibiting EMT-induced by chemotherapy by GSK3beta inhibiting drugs. In order to investigate the safety and antitumor response to this combination of GSK3beta inhibiting drugs, Investigator initiated phase I clinical trial are conducted with advanced pancreatic cancer. This research may contribute to the development of a new pancreatic cancer treatment.
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[Journal Article] Aberrant glycogen synthase kinase 3βis involved in pancreatic cancer cell invasion and resistance to therapy2013
Author(s)
Kitano A, Shimasaki T, Chikano Y, Nakada M, Hirose M, Higashi T, Ishigaki Y, Endo Y, Takino T, Sato H, Sai Y, Miyamoto K, Motoo Y, Kawakami K, Minamoto T.
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Journal Title
PLoS One
Volume: 8(2)
Pages: e55289
Peer Reviewed
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[Journal Article] Glycogen synthase kinase 3βinhibition sensitizes pancreatic cancer cells to gemcitabine2012
Author(s)
Shimasaki T, Ishigaki Y, Nakamura Y, Takata T, Nakaya N, Nakajima H, Sato I, Zhao X, Kitano A, Kawakami K, Tanaka T, Takegami T, Tomosugi N, Minamoto T, Motoo Y.
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Journal Title
J Gastroenterol
Volume: 47(3)
Pages: 321-33
Peer Reviewed
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