2013 Fiscal Year Final Research Report
An immunological study of pthogenesis in autoimmune pancreatitis
| Project/Area Number |
23591017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIO Akiyoshi 関西医科大学, 医学部, 准教授 (50362463)
UCHIDA Kazushige 関西医科大学, 医学部, 講師 (40411516)
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| Project Period (FY) |
2011 – 2013
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| Keywords | IgG4関連疾患 / 自己免疫性膵炎 / IgG4 / 制御性T細胞 / 制御性B細胞 / 自然免疫 |
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| Research Abstract |
(1)In pancreas cancer and obstructive pancreatitis type 1 AIP, infiltration of memory regulatory T cells (Tregs) and IgG4-positive cells were positively correlated, which suggested that increased memory-Tregs may be an inhibitory immune response against inflammation, although decreased naïve Tregs may be pathogenic. (2) We identified two subtypes of regulatory B cells (Bregs), CD19+CD24highCD38high Bregs and CD19+CD24highCD27+ Bregs in type 1 AIP. The increased CD19+CD24highCD38high Bregs may suppress the disease activity of type 1 AIP, whereas the decreased CD19+CD24highCD27+ Bregs might be involved in the development of type 1 AIP. (3) In animal models, activation of TLR3 (polyinosinic:polycytidylic acid) can induce immune-mediated cholangitis, pancreatitis and sialadenitis similar to human autoimmune pancreatitis.
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Research Products
(32 results)
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[Journal Article] Possible Involvement of Foxp3(+) Regulatory T Cells in the Development of Immune-Mediated Pancreatitis in MRL/Mp Mice Treated with Polyinosinic : Polycytidylic Acid2013
Author(s)
Koyabu M, Uchida K, Sakaguchi Y, Fukata N, Kusuda T, Miyoshi H, Yoshida K, Sumimoto K, Mitsuyama T, Fukui T, Nishio A, Okazaki K
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Journal Title
Int J Rheumatol
Volume: 2013 (367325)
DOI
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[Journal Article] A proposal of a diagnostic algorithm with validation of International Consensus Diagnostic Criteria for autoimmune pancreatitis in a Japanese cohort2013
Author(s)
Sumimoto K, Uchida K, Mitsuyama T, Fukui Y, Kusuda T, Miyoshi H, Tomiyama T, Fukata N, Koyabu M, Sakaguchi Y, Ikeura T, Shimatani M, Fukui T, Matsushita M, Takaoka M, Nishio A, Okazaki K
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Journal Title
Pancreatology
Volume: 13(3)
Pages: 230-7
DOI
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[Journal Article] The similarity of Type 1 autoimmune pancreatitis to pancreatic ductal adenocarcinoma with significant IgG4-positive plasma cell infiltration2013
Author(s)
Fukui Y, Uchida K, Sumimoto K, Kusuda T, Miyoshi H, Koyabu M, Ikeura T, Sakaguchi Y, Shimatani M, Fukui T, Matsushita M, Takaoka M, Nishio A, Shikata N, Sakaida N, Uemura Y, Satoi S, Kwon AH, Okazaki K
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Journal Title
J Gastroenterol
Volume: 48(6)
Pages: 751-61
DOI
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[Journal Article] Regulatory T cells in type 1 autoimmune pancreatitis2012
Author(s)
Uchida K, Kusuda T, Koyabu M, Miyoshi H, Fukata N, Sumimoto K, Fukui Y, Sakaguchi Y, Ikeura T, Shimatani M, Fukui T, Matsushita M, Takaoka M, Nishio A, Okazaki K
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Journal Title
Int J Rheumatol
Volume: 2012 (795026)
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[Journal Article] Autoimmune pancreatitis with histologically proven lymphoplasmacytic sclerosing pancreatitis with granulocytic epithelial lesions2012
Author(s)
Ikeura T, Takaoka M, Uchida K, Shimatani M, Miyoshi H, Kusuda T, Kurishima A, Fukui Y, Sumimoto K, Satoi S, Ohe C, Uemura Y, Kwon AH, Okazaki K
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Journal Title
Intern Med
Volume: 51(7)
Pages: 733-7
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[Journal Article] Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 20112012
Author(s)
Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H, Inui K, Ohara H
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Journal Title
Mod Rheumatol
Volume: 22(1)
Pages: 21-30
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[Presentation] Comparison of International Consensus Diagnostic Criteria and Major Diagnostic Criteria for Autoimmune Pancreatitis2012
Author(s)
Sumimoto , Uchida K, Fukui K, Kusuda , Hideaki Miyoshi, Norimasa Fukata, Masanori Koyabu, Yutaku Sakaguchi, Tsukasa Ikeura, Masaaki Shimatani, Toshiro Fukui, Mitsunobu Matsushita, Makoto Takaoka, Akiyoshi Nishio, Okazaki K
Organizer
DDW2012
Place of Presentation
San Diego, California, USA
Year and Date
2012-05-20
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