2013 Fiscal Year Final Research Report
The risk factor of fibrous stricture in Crohn' s disease
| Project/Area Number |
23591019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | クローン病 / 腸管狭窄 / 線維化マーカー |
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| Research Abstract |
Because a surgical intestinal resection is usually necessary when small intestinal stenosis in Crohn disease results in ileus once, the stenosis prevention is important. However, a prediction of stenosis occurring has been difficult due to gradual progression without a symptom. We have studied whether some materials in blood sample could be the predictive factor of patients with stenosis, and whether a certain drug could prevent the intestinal stenosis.
In basic experiment, it was found that 6-MP attenuated TGF-beta production of fibrobrast, which is one of important cytokines related with fibrosis. In patients having some stenosis, TGF-beta indicated high, but data fluctuation among patients was not able to conclude with the prediction factor. Unfortunately, there were no relationship between the concentration of 6-TGN, which is metabolite of 6-MP, and TGF-beta.
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