2013 Fiscal Year Final Research Report
Predictor of lymph node metastasis using molecular marker for submucosal invasive gastric cancer
| Project/Area Number |
23591021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hiroshima University |
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Principal Investigator |
OKA SHIRO 広島大学, 大学病院, 病院助教 (30403538)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Shinji 広島大学, 病院, 教授 (00260670)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 胃SM癌 / リンパ節転移 / 内視鏡的根治判定基準 / 分子病理学的マーカー / 未分化型胃癌 |
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| Research Abstract |
We evaluated the expressions of micro satellite instability (BAT26) and mitochondria DNA between the surface and the deeper site of submucosal invasive early gastric cancers, which were indication of non-curative after endoscopic resection. However, there was no significant difference of these molecular markers' expression between these sites (no heterogeneity). These data suggested that it is not clinically usefulness to predict lymph node metastasis from the biopsy specimen of submucosal invasive gastric cancer using molecular marker.
The incidence of lymph node metastasis of submucosal invasive undifferentiated-type early gastric cancers was high regardless of their clinicopathologic factors. The expanded criteria (ulcer-negative, intramucosal cancer 20mm or less without lymphovascular invasion)of endoscopic resection for undifferentiated-type early gastric cancer was pertinent based on long-term outcomes.
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