2014 Fiscal Year Final Research Report
Adaptive servo-ventilation improves cardiac sympathetic nerve activity in patients with heart failure: Evaluation by cardiac 11C-Hydroxyephedrine positron emission tomography
Project/Area Number |
23591024
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TSUTSUI Hiroyuki 北海道大学, 大学院医学研究科, 教授 (70264017)
KINUGAWA Shintaro 北海道大学, 大学院医学研究科, 講師 (60399871)
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Co-Investigator(Renkei-kenkyūsha) |
YOSHINAGA Keiichiro 北海道大学, 大学院医学研究科, 特任教授 (30435961)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Keywords | 交感神経活性 / ASV / 慢性心不全 |
Outline of Final Research Achievements |
Aims: ASV has been shown to improve cardiac function in patients with heart failure (HF). The sympathetic overactivation is associated with a poor prognosis of HF patients, we investigated whether ASV could improve cardiac sympathetic nerve activity in patients with HF. Methods: Nine HF patients (age: 57.3±17.3 years old, male: 6) We performed echocardiography, polysomnography, and the evaluation of the cardiac sympathetic nerve activity before and after 9weeks of ASV. Cardiac presynaptic innervation was analyzed by 11C-hydroxyephedrine (HED) retention assessed with positron emission tomography (PET).Result: LVEF tended to improve after ASV, although there was no statistical significant difference Global 11C-HED retention index improved from 0.068±0.032 to 0.089±0.045 (p=0.0404). Conclusion: We could evaluate cardiac sympathetic nerve activity by HED-PET, and ASV improved cardiac sympathetic nerve activity in patients with HF.
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Free Research Field |
循環器内科
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