• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Study on circadian changes in sympathetic tone in subtotal nephrectomized rats with heart failure

Research Project

  • PDF
Project/Area Number 23591033
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of Toyama

Principal Investigator

INOUE Hiroshi  富山大学, 事務局, 理事・副学長 (60151619)

Co-Investigator(Kenkyū-buntansha) HIRAI Tadakazu  富山大学, 大学病院, 講師 (10303215)
JOHO Shuji  富山大学, 大学院医学薬学研究部(医学), 助教 (90334721)
Project Period (FY) 2011 – 2013
Keywords心不全 / 心腎連関 / 自律神経機能
Research Abstract

We studied whether chronic kidney disease (CKD) could alter circadian changes in autonomic function in rats with heart failure (HF). Rats underwent subtotal nephrectomy and surgically induced myocardial infarction as a potential model of cardiorenal syndrome. After acclimatization to a 12h light-dark cycle, blood pressure, heart rate and locomotor activity were continuously recorded for 24 - 48 hours in conscious, unrestrained rats by using instrumented radiotelemetry pressure transducer. During the awakening period, low frequency components of diastolic blood pressure variability, an index of sympathetic tone, were more exaggerated in HF rats with CKD than in HF rats without CKD. Hypercapnic chemosensitivity evaluated by hourly intermittent CO2 exposure was transiently increased during the awakening period in HF rats with CKD, suggesting that central chemosensitivity could be related to the exaggerated sympathetic tone in cardiorenal syndrome.

  • Research Products

    (21 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (9 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Fluvastatin- induced reduction of oxidative stress ameliorates diabetic cardiomyopathy in association with improving coronary microvasculature2013

    • Author(s)
      Shida T, Nozawa T, Sobajima M, Ihori H, Matsuki A, Inoue H.
    • Journal Title

      Heart Vessels

      Volume: Aug 25(in press)

    • Peer Reviewed
  • [Journal Article] Heart rate- reducing effects of bisoprolol in Japanese patients with chronic atrial fibrillation : results of the MAIN-AF study2013

    • Author(s)
      Yamashita T, Inoue H.
    • Journal Title

      J Cardiol

      Volume: 62 Pages: 50-7

    • DOI

      10.1016/j.jjcc.2013.02.010

    • Peer Reviewed
  • [Journal Article] Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction2013

    • Author(s)
      Nakatani Y, Nishida K, Sakabe M, Kataoka N, Sakamoto T, Yamaguchi Y, Iwamoto J, Mizumaki K, Fujiki A, Inoue H.
    • Journal Title

      J Am Coll Cardiol

      Volume: 61 Pages: 582-8

    • DOI

      10.1016/j.jacc.2012.11.014

    • Peer Reviewed
  • [Journal Article] Repeated sauna therapy improves myocardial perfusion in patients with chronically occluded coronary artery-related ischemia2013

    • Author(s)
      Sobajima M, Nozawa T, Ihori H, Shida T, Ohori T, Suzuki T, Matsuki A, Yasumura S, Inoue H.
    • Journal Title

      Int J Cardiol

      Volume: 167 Pages: 237-43

    • DOI

      10.1016/j.ijcard.2011.12.064

    • Peer Reviewed
  • [Journal Article] Effect of adaptive servo-ventilation on muscle sympathetic nerve activity in patients with chronic heart failure and central sleep apnea2012

    • Author(s)
      Joho S, Oda Y, Ushijima R, Hirai T, Inoue H.
    • Journal Title

      J Card Fail

      Volume: 18 Pages: 769-75

    • DOI

      10.1016/j.cardfail.2012.08.360

    • Peer Reviewed
  • [Journal Article] Vagal activity modulates spontaneous augmentation of J-wave elevation in patients with idiopathic ventricular fibrillation2012

    • Author(s)
      Mizumaki K, Nishida K, Iwamoto J, Nakatani Y, Yamaguchi Y, Sakamoto T, Tsuneda T, Kataoka N, Inoue H.
    • Journal Title

      Heart Rhythm

      Volume: 9 Pages: 249-55

    • DOI

      10.1016/j.hrthm.2011.09.055

    • Peer Reviewed
  • [Journal Article] Effect of repeated sauna treatment on exercise tolerance and endothelial function in patients with chronic heart failure2012

    • Author(s)
      Ohori T, Nozawa T, Ihori H, Shida T, Sobajima M, Matsuki A, Yasumura S, Inoue H.
    • Journal Title

      Am J Cardiol

      Volume: 109 Pages: 100-4

    • DOI

      10.1016/j.amjcard.2011.08.014

    • Peer Reviewed
  • [Presentation] Enhanced sympathetic tone during the awakening period in nephrectomized rats with myocardial infarction2013

    • Author(s)
      Hirai T, Numa S, Ohori T, Joho S, Nozawa T, Asanoi H, Inoue H.
    • Organizer
      第17回日本心不全学会学術集会
    • Place of Presentation
      大宮
    • Year and Date
      20131128-30
  • [Presentation] Circadian changes in ventricular and atrial late potentials correlate with ventricular and atrial vulnerability in patients with dilated cardiomyopathy2013

    • Author(s)
      Kataoka N, Mizumaki K, Yamaguchi Y, Nishida K, Sakamoto T, Inoue H.
    • Organizer
      The 34th Annual Scientific Session of the Heart Rhythm Society
    • Place of Presentation
      Denver
    • Year and Date
      20130908-11
  • [Presentation] Hyponatremia is associated with increased muscle sympathetic nerve activity in patients with heart failure2013

    • Author(s)
      Akabane T, Joho S, Ushijima R, Inoue H.
    • Organizer
      European Society of Cardiology 2013
    • Place of Presentation
      Amsterdam
    • Year and Date
      20130831-0904
  • [Presentation] Repeated low- emperature sauna therapy improves cardiac and exercise capacity as well as immune competence in patients with heart failure2012

    • Author(s)
      Sobajima M, Nozawa T, Ihori H, Ohori T, Shida T, Fujii N, Inoue H.
    • Organizer
      American Heart Association Scientific Sessions 2012
    • Place of Presentation
      Los Angeles
    • Year and Date
      20121103-07
  • [Presentation] Effect of adaptive servo-ventilation on muscle sympathetic nerve activity and cardiac function in patients with chronic heart failure2012

    • Author(s)
      Joho S, Ushijima R, Oda Y, Hirai T, Inoue H.
    • Organizer
      European Society of Cardiology Congress 2012
    • Place of Presentation
      Munich
    • Year and Date
      20120825-29
  • [Presentation] Short term effect of adaptive servo-ventilation compared with continuous positive airway pressure on muscle sympathetic nerve activity in patients with heart failure2012

    • Author(s)
      Ushijima R, Joho S, Oda Y, Hirai T, Inoue H.
    • Organizer
      European Society of Cardiology Congress 2012
    • Place of Presentation
      Munich
    • Year and Date
      20120825-29
  • [Presentation] Influence of sympathetic nerve activity on central sleep apnea in patients with heart failure2011

    • Author(s)
      Joho S, Ushijima R, Oda Y, Harada D, Hirai T, Inoue H.
    • Organizer
      European society congress 2011
    • Place of Presentation
      Paris
    • Year and Date
      20110827-31
  • [Presentation] Sympathetic overactivation in dilated phase of hypertrophic cardiomyopathy2011

    • Author(s)
      Ushijima R, Joho S, Oda Y, Harada D, Hirai T, Asanoi H, Inoue H.
    • Organizer
      European society congress 2011
    • Place of Presentation
      Paris
    • Year and Date
      20110827-31
  • [Presentation] Adaptive servo-ventilation attenuates muscle sympathetic nerve activity in heart failure patients with renal dysfunction2011

    • Author(s)
      Harada D, Joho S, Oda Y, Hirai T, Asanoi H, Inoue H.
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      横浜
    • Year and Date
      20110803-04
  • [Book] 循環器系疾患の症候のとらえ方.井上博他編,「今日の循環器疾患治療指針第3版」2013

    • Author(s)
      井上博
    • Total Pages
      7-10
    • Publisher
      医学書院
  • [Book] 心電図.矢崎義雄総編.「内科学10版」2013

    • Author(s)
      井上博
    • Total Pages
      429-436
    • Publisher
      中山書店
  • [Book] 心房細動・心房粗動.堀正二,永井良三編,「循環器疾患最新の治療2012-2013」2012

    • Author(s)
      井上博
    • Total Pages
      323-327
    • Publisher
      南江堂
  • [Book] 発作性上室頻拍.奥村謙編,「ガイドライン/ガイダンス不整脈」2011

    • Author(s)
      井上博
    • Total Pages
      55-60
    • Publisher
      日本医事新報社
  • [Remarks]

    • URL

      http://www.med.u-toyama.ac.jp/inter2/research/

URL: 

Published: 2015-07-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi