2013 Fiscal Year Final Research Report
Effects of remote ischemic conditioning on coronary endothelial vasomotor function in patients treated with drug eluting stents
| Project/Area Number |
23591034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OBATA Jun-ei 山梨大学, 医学部附属病院, 講師 (60362076)
KITTA Yoshinobu 山梨大学, 医学部附属病院, 助教 (10377509)
KAWABATA Kenichi 山梨大学, 医学部附属病院, 講師 (30345706)
FUJIOKA Daisuke 山梨大学, 医学部附属病院, 助教 (70377513)
KUGIYAMA Kiyotaka 山梨大学, 医学工学総合研究部, 教授 (00225129)
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| Project Period (FY) |
2011 – 2013
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| Keywords | Remote conditioning / DES / 内皮機能 |
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| Research Abstract |
In this study, we investigated the effects of remote ischemic conditioning in acute coronary syndrome (ACS) patients treated with drug-eluting stents (DES). Fifty ACS patients were randomly assigned to receive remote ischemic conditioning (remotecon) or as control before DES implantation. All patients were followed up for <2 years or until the occurrences of coronary events including cardiac death, non-fatal myocardial infarction, and unstable angina requiring revascularization therapy. During follow up periods, 9 coronary events were observed. However, there were no significant differences in occurrence of coronary events between 2 groups (4patients [16%], in remote con, vs. 5 patients [20%], in control, p = 0.48). Moreover, assessment of vasomotor function in the infarct-related artery at 14 days in a subgroup of 30 patients showed that there was a trend in preservation of endothelial vasomotor function in remotecon group compared with control.
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