The mechanism of cardio-renal interaction in heart failure-the approach from functional renal reserve-

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: MANO Toshiaki 大阪大学, 医学部附属病院, 講師 (90379165)
• Co-Investigator(Kenkyū-buntansha): SAKATA Yasushi 大阪大学, 医学系研究科, 教授 (00397671) ; YAMAMOTO Kazuhiro 鳥取大学, 医学系研究科, 教授 (90303966)
• Project Period (FY): 2011 – 2013
• Keywords: 心腎連関 / 腎予備力 / 心不全

Research Abstract

Decreased renal function is an independent risk for cardiovascular adverse outcomes in patients with heart failure. However, the impact of renal function, especially functional renal reserve on the pathophysiology of heart failure remains unknown. This study clarified that intrarenal vascular resistance as a physiological parameter of functional renal reserve plays an important role in the development of heart failure with preserved ejection fraction (HFpEF) and the existence of a cytokine specific for HFpEF and diastolic dysfunction from comprehensive screening.

Research Products

• [Journal Article] Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction (2013)
  • Author(s): Tamaki S, Mano T, Sakata Y, Ohtani T, Takeda Y, Kamimura D, Omori Y, Tsukamoto Y, Ikeya Y, Kawai M, Kumanogoh A, Hagihara K, Ishii R, Higashimori M, Kaneko M, Hasuwa H, Miwa T, Yamamoto K, Komuro I.
  • Journal Title: PlosOne Volume: 8 Pages: e68893
  • DOI: 10.1371/journal.pone.0068893
  • Peer Reviewed
• [Journal Article] L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease (2012)
  • Author(s): Omori Y, Ohtani T, Sakata Y, Mano T, Takeda Y, Tamaki S, Tsukamoto Y, Kamimura D, Aizawa Y, Miwa T, Komuro I, Soga T, Yamamoto K.
  • Journal Title: J Hypertens Volume: 30 Pages: 1834-44
  • DOI: 10.1097/HJH.0b013e3283569c5a
  • Peer Reviewed
• [Presentation] Interleukin-16 is associated with diastolic dysfunction, promotes cardiac fibrosis and accelerates myocardial stiffening in heart failure with preserved ejection fraction (2013)
  • Author(s): 真野敏昭、玉置俊介
  • Organizer: 日本心不全学会学術集会
  • Place of Presentation: 大宮
  • Year and Date: 20131100
• [Patent(Industrial Property Rights)] 拡張性心不全を治療、診断するため の組成物およびその利用 (2014)
  • Inventor(s): 真野敏昭 坂田泰史 玉置俊介 萩 原圭祐
  • Industrial Property Rights Holder: 真野敏昭 坂田泰史 玉置俊介 萩 原圭祐
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特許出願2013-018992
  • Filing Date: 2014-01-17
  • Overseas