2013 Fiscal Year Final Research Report
Insulin Resistance as Promoters for Developemnts of Aortic Valve Sclerosis and Coronary Artery Disease
| Project/Area Number |
23591044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIHARA Yasuki 広島大学, 医歯薬保健学研究院, 教授 (40214853)
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| Project Period (FY) |
2011 – 2013
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| Keywords | インスリン抵抗性 / 弁膜石灰化 / 冠動脈 / アディポネクチン |
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| Research Abstract |
1. We studied patients with aortic valvular calcification (AVC) assessed by echocardiography had higher rates of induced myocardial ischemia, especially in diabetes mellitus (DM) patients. 2. When AVC scores were measured by cardiac CT, higher AVC score was an independent predictor of cardiac mortality in aortic stenosis (AS) patients. 3. Echocardiographic heart calcification score, the sum of the amounts of AVC, mitral annular, and aortic root calcification, has an independent and incremental prognostic value in a high-risk population. 4. Assessed by two-dimensional speckle-tracking echocardiography, insulin resistance is a powerful independent predictor of subclinical left ventricular dysfunction in patients with AVC and thus may be a novel therapeutic target to prevent subsequent heart failure.
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