Risk Assessment of Cardiovascular Events by Meta-Analysis of Genome-Wide Association Studies for Atrial Fibrillation in Patients With Heart Failure

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591048
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Ehime University
• Principal Investigator: OGIMOTO AKIYOSHI 愛媛大学, 医学部附属病院, 准教授 (00403832)
• Project Period (FY): 2011 – 2013
• Keywords: 心筋症 / 遺伝子解析 / 心血管事故 / リスク層別化

Research Abstract

A meta-analysis of genome-wide association studies for atrial fibrillation (AF) has successfully identified ten genotypes. We conducted a cross-sectional study to clarify the association between cumulative effects of GWAS-proved single nucleotide polymorphisms (SNPs) and AF in patients with heart failure.
One hundred seventy-two patients with heart failure were enrolled. One hundred twenty-six were diagnosed with AF. We genotyped 10 SNPs validated by meta-analysis of GWAS for AF. Ten SNPs were KCNN3-PMVK(rs6666258), PRRX1(rs3903239), PITX2(rs6817105), WNT8A(rs2040862), CAV1(rs3807989), C9orf3(rs10821415), SYNPO2L(rs10824026), SYNE2(rs1152591), HCN4(rs7164883), and ZFHX3(rs2106261). Cumulative effects were calculated as a genotype risk score (GRS) by adding the risk allele number of 10 SNPs. Mean GRS in patients with AF was significantly higher than that in patients with sinus rhythm. We found that the GRS was significantly associated with AF in patients with heart failure.

Research Products

• [Journal Article] Possible role of angiotensin-converting enzyme 2 and activation of angiotensin II type 2 receptor by angiotensin-(1-7) in improvement of vascular remodeling by angiotensin II type 1 receptor blockade (2014)
  • Author(s): Ohshima K, Mogi M, Nakaoka H, Iwanami J, Min LJ, Kanno H, Tsukuda K, Chisaka T, Bai HY, Wang XL, Ogimoto A, Higaki J, Horiuchi M.
  • Journal Title: Hypertension Volume: 63 Pages: e53-9
  • Peer Reviewed
• [Journal Article] Positron Emission Tomography Computed Tomography for Imaging of Inflammatory Cardiovascular Diseases (2014)
  • Author(s): Miyagawa M, Yokoyama R, Nishiyama Y, Ogimoto A, Higaki J, Mochizuki T.
  • Journal Title: Circ J Volume: May 9(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Relationship Between Augmentation Index and Left Ventricular Diastolic Function in Healthy Women and Men (2013)
  • Author(s): Higashi H, Okayama H, Saito M, Morioka H, Aono J, Yoshii T, Hiasa G, Sumimoto T, Nishimura K, Inoue K, Ogimoto A, Higaki J.
  • Journal Title: Am J Hypertens Volume: Jul 17(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Role of transthoracic Doppler echocardiography in patients with a proximal left coronary artery lesion that cannot be diagnosed by computed tomography angiography (2013)
  • Author(s): Higashi H, Okayama H, Saito M, Morioka H, Aono J, Yoshii T, Sumimoto T, Hiasa G, Nishimura K, Inoue K, Ogimoto A, Higaki J.
  • Journal Title: Am J Cardiol Volume: 112 Pages: 938-42
  • Peer Reviewed
• [Journal Article] Qualitative and quantitative assessment of adenosine triphosphate stress whole-heart dynamic myocardial perfusion imaging using 256-slice computed tomography (2013)
  • Author(s): Kurata A, Kawaguchi N, Kido T, Inoue K, Suzuki J, Ogimoto A, Funada J, Higaki J, Miyagawa M, Vembar M, Mochizuki T.
  • Journal Title: PLoS One Volume: 8 Pages: e83950
  • Peer Reviewed
• [Journal Article] 遺伝子から診た特発性心筋症 (2013)
  • Author(s): 藤本香織,大木元明義,大蔵隆文,檜垣實男
  • Journal Title: 愛媛医学 Volume: 32 Pages: 165-70
  • Peer Reviewed
• [Journal Article] 心室中隔中部に憩室様の菲薄化をきたした心サルコイドーシスの1例 (2013)
  • Author(s): 村上千佳,永井啓行,飯尾千春子,藤井昭,西村和久,井上勝次,鈴木純,宮川正男,望月輝一,檜垣實男,大木元明義
  • Journal Title: 心臓 Volume: 45 Pages: 1007-12
  • Peer Reviewed
• [Presentation] Impact of SCN10A Gene Polymorphism for Cardiac Conduction Abnormality in Patients with Hypertrophic Cardiomyopathy (2014)
  • Author(s): Ogimoto A, Iio C, Kono T, Fujii A, Uetani T, Nagai T, Nishimura K, Inoue K, Suzuki J, Okura T, Higaki J.
  • Organizer: The American College of Cardiology 63^<rd> Annual Scientific Session
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20140329-31
• [Presentation] The Impact of Adaptive-Servo Ventilator on Coronary Flow Velocity Reserve in Patients With Non-ischemic Dilated Cardiomyopathy (2014)
  • Author(s): Nishimura K, Inoue K, Uetani T, Nagai T, Suzuki J, Ogimoto A, Okura T, Higaki J.
  • Organizer: The American College of Cardiology 63^<rd> Annual Scientific Session
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20140329-31
• [Presentation] Diagnostic Accuracy of ATP-Stress Dynamic CT Perfusion Imaging as Compared with ATP-Stress Cardiac MR Perfusion Imaging for the Assessment of Myocardial Ischemia (2014)
  • Author(s): Uetani T, Ogimoto A, Kono T, Fujii A, Nagai T, Nishimura K, Inoue K, Suzuki J, Okura T, Higaki J.
  • Organizer: The American College of Cardiology 63^<rd> Annual Scientific Session
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20140329-31
• [Presentation] Cumulative Genetic Risk of Single Nucleotide Polymorphisms by Meta-Analysis of Genome-Wide Association Studies for Atrial Fibrillation (2014)
  • Author(s): Fujii A, Ogimoto A, Nagai T, Suzuki J, Inoue K, Nishimura K, Uetani T, Tabara Y, Miki T, Okura T, Higaki J.
  • Organizer: The 78^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
  • Year and Date: 20140321-23
• [Book] 第4章治療薬総論禁煙補助薬禁煙補助薬 (2013)
  • Author(s): 分担執筆大木元明義,檜垣實男, 今日の循環器疾患治療指針第3版編集井上博,許俊鋭,檜垣實男,代田浩之,筒井裕之
  • Total Pages: 186-187
  • Publisher: 医学書院
• [Remarks]
  • URL: http://www.m.ehime-u.ac.jp/school/int.med2/index.html