2013 Fiscal Year Final Research Report
Pathogenesis of abdominal aortic aneurysm and role of glycolysis restriction as a potential medical therapy
| Project/Area Number |
23591052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Kazuo 宮崎大学, 医学部, 教授 (50204912)
HATAKEYAMA Kinta 宮崎大学, 医学部, 准教授 (60325735)
NAGAMACHI Shigeki 宮崎大学, 医学部, 准教授 (40180517)
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| Co-Investigator(Renkei-kenkyūsha) |
ASADA Yujiro 宮崎大学, 医学部, 教授 (70202588)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血管生物学 / マクロファージ / 解糖系 / 動脈瘤 |
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| Research Abstract |
Enhanced accumulation of the modified glucose analogue 18fluoro-deoxyglucose by positron emission tomography imaging in the human abdominal aortic aneurysm (AAA) was associated with protein expressions of glucose transporters-1 and -3, assessed by Western blot. The magnitude of glucose transporter-3 expression was correlated with matrix metalloproteinase (MMP)-9 activity, co-localized in macrophages of the aneurysmal wall. In monocytic cell line induced by phorbol 12-myristate 13-acetate, the inhibition of glucose transport or glycolysis abrogated the MMP-9 activity in these cells. Furthermore, the inhibition of glycolysis activity with the intra-peritoneal administration of 2-deoxyglucose significantly attenuated the dilatation of abdominal aorta induced by periaortic application of calcium chloride in C57BL/6J male mice or reduced the aneurysmal formation in angiotensin II-infused apolipoprotein E knockout male mice.
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[Journal Article] Inhibition of development of abdominal aortic aneurysm by glycolysis restriction2012
Author(s)
Tsuruda T, Hatakeyama K, Nagamachi S, Sekita Y, Sakamoto S, Endo GJ, Nishimura M, Matsuyama M, Yoshimura K, Sato Y, Onitsuka T, Imamura T, Asada Y, Kitamura K
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32
Pages: 1410-1417
Peer Reviewed
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