2014 Fiscal Year Final Research Report
Combination revascularization therapy using peripheral mononuclear cell and adrenomedullin for patients with peripheral artery disease
| Project/Area Number |
23591053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 循環器 / 再生医療 / アドレノメデュリン / 末梢血単核球移植術 / 臨床 |
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| Outline of Final Research Achievements |
We assessed effectiveness of combination therapy that consisted with therapeutic revascularization using peripheral mononuclear cells and continuous infusion of adrenomedullin (AM) (1.5 pmol/kg/min X 8 hr/day for 2 weeks) for severe ischemic limb of patients with peripheral artery disease who had not responded to conventional therapy. We conducted a randomized, double-blind, placebo-controlled trial. Four patients, 2 with AM and 2 with placebo, were treated and one patient in each group was followed over 1 year. Favorable effect was continued for 1 year and 6 months in patient with AM. In placebo group, 1 patient sustained therapeutic effect for 1 year, but another 1 patient underwent foot amputation within several months.
We cannot conducted enough evaluation from small number of the patients, but we collected valuable experience and knowledge through the trial, and the information is contributed as a base of the plan in investigator initiated trials using AM which is now in progress.
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| Free Research Field |
循環器内科学
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