Screening for sleep disordered breathing by Holter electrocardiograms

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591055
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Nagoya City University
• Principal Investigator: HAYANO Junichiro 名古屋市立大学, 医学(系)研究科(研究院), 教授 (90173054)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 睡眠時無呼吸 / ホルター心電図 / 心拍変動 / コンピュータ / 死亡率 / うつ病

Outline of Final Research Achievements

Despite the adverse cardiovascular consequences of sleep disordered breathing (SDB), the majority of patients remain undiagnosed. To establish an effective ECG-based screening tool for SDB, we developed an automated algorithm (ACAT) that detects cyclic variation of heart rate accompanying SDB episodes. Among 862 patients undergoing polysomnographic examination, the ACAT detected moderate-to-severe SDB with 83% sensitivity and 88% specificity. The ACAT also detected SDB patients among 165 apparently healthy track drivers in a transportation company. Furthermore, we applied the ACAT algorithm to Holter ECG recordings in 716 patients after an acute myocardial infarction and found that depression and SDB are interactively associated with increased mortality risk during a median follow-up of 25 months.

Free Research Field

循環器内科学