Development of Cardiovascular Risk Scoring System for Japanses Population

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591059
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Iwate Medical University
• Principal Investigator: NAKAMURA Motoyuki 岩手医科大学, 医学部, 教授 (40172449)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Fumitaka 岩手医科大学, 医学部, 講師 (80405761) ; MAKITA Shinji 岩手医科大学, 医学部, 助教授 (60306024) ; SAKATA Kiyomi 岩手医科大学, 医学部, 教授 (50225794) ; ONODA Toshiyuki 岩手医科大学, 医学部, 准教授 (00254748)
• Project Period (FY): 2011 – 2013
• Keywords: 脳卒中 / 心筋梗塞 / 突然死 / 心不全 / リスク / 予測 / コホ－ト

Research Abstract

Several studies have suggested usefulness of new biomarkers (high-sensitive CRP, BNP, urine albumin) for cardiovascular events (CVE) in western population. However, feasibility of these markers for predicting CVE remains unknown in the Japanese population. We have reported usefulness of these biomarkers including lipoprotein ratio for predicting stroke, heart failure, and myocardial infarction in our population. Of these markers, the predictive value of plasma BNP singly or combination with other markers is similar or superior to compare with that of the established scoring system. On the basis of these reports, we are exploring a novel and useful scoring system for predicting CVE in the Japanese general population.

Research Products

• [Journal Article] Usefulness of Risk Grading System using Albuminuria for Predicting Cardiovascular Events and All-cause Death in Chronic Kidney Disease : A Population-based Prospective Cohort Study in Japan (2014)
  • Author(s): Koeda Y, Tanaka F, Segawa T, Ohta M, Ohsawa M, Tanno K, Makita S, Ishibashi Y, Omama S, Onoda T, Nakamura M
  • Journal Title: Int J Cardiol Volume: (Available online)
  • DOI: 10.1016/j.ijcard.2014.05.026
  • Peer Reviewed
• [Journal Article] Population‐Based Incidence of Sudden Cardiac and Unexpected Death Before and After the 2011 Earthquake and Tsunami in Iwate, Northeast Japan (2014)
  • Author(s): Niiyama M, Tanaka F, Nakajima S, Ito T, Matsumoto T, Kawakami M, Naganuma Y, Omama S, Komatsu T, Onoda T, Sakata K, Ichikawa T, Nakamura M
  • Journal Title: J Am Heart Assoc Volume: 3 Pages: e000798
  • DOI: 10.1161/JAHA.114.000798
  • Peer Reviewed
• [Journal Article] Cardiovascular risk stratification with plasma B-type natriuretic peptide levels in a community-based hypertensive cohort (2014)
  • Author(s): Sato K, Segawa T, Tanaka F, Takahashi T, Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Omama, S Ogasawara K, Ishibashi Y, Makita S, Okayama A, Nakamura M
  • Journal Title: Am J Cardiol Volume: 113 Pages: 682-686
  • DOI: 10.1016/j.amjcard.2013.11.012
  • Peer Reviewed
• [Journal Article] Plasma B-type Natriuretic Peptide as a Predictor of Cardiovascular Events in Subjects with Atrial Fibrillation : A Community-Based Study (2013)
  • Author(s): Nakamura M, Koeda Y, Fumitaka T, Onoda T, Itai K, Ohsawa M, Tanno T, Sakata K, Omama S, Ishibashi Y, Makita S, Ohta M, Ogasawara K, Komatsu T, Okayama A
  • Journal Title: PLoS One Volume: 8(12) Pages: e81243
  • DOI: 10.1371/journal.pone.0081243
  • Peer Reviewed
• [Journal Article] Predictive value of lipoprotein indices for residual risk of acute myocardial infarction and sudden death in men with low-density lipoprotein cholesterol levels <120mg/dl (2013)
  • Author(s): Tanaka F, Makita S, Onoda T, Tnnno k, Ohsawa M, Itai K, Sakata K, Omama S, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Okayama A, Nakamura M, on behalf of the Iwate-Kenco Study Group
  • Journal Title: Am J Cardiol Volume: 112(8) Pages: 1063-1068
  • DOI: 10.1016/j.amjcard.2013.05.049
  • Peer Reviewed
• [Journal Article] Comparison of utility of arterial stiffness parameters for predicting cardiovascular events in the general population (2013)
  • Author(s): Ishisone T, Koeda Y, Tanaka F, Sato K,Nagano M, Nakamura M
  • Journal Title: IntHeart J Volume: 54(3) Pages: 160-165
  • DOI: 10.1536/ihj.54.160
  • Peer Reviewed
• [Journal Article] Influence of the great East Japan earthquake and tsunami 2011 on occurrence of cerebrovascular diseases in Iwate, Japan (2013)
  • Author(s): Omama S, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Nakamura M, Tanno K,Ohsawa M, Onoda T, Itai K, Sakata K
  • Journal Title: Stroke Volume: 44 Pages: 1518-1524
  • DOI: 10.1161/STROKEAHA.111.000442
  • Peer Reviewed
• [Journal Article] Comparison of predictability of future cardiovascular events between Chronic Kidney Disease (CKD) stage based on CKD epidemiology collaboration equation and that based on modification of diet in renal disease equation in the Japanese general population (2013)
  • Author(s): Ohsawa M, Tanno K, Itai K, Tanivir Chowdhury Turin,Okamura T, Ogawa A,Ogasawara K, Fujioka T, Onoda T, Yoshida Y, Omama S, Ishibashi Y,Nakamura M, Makita S, Tanaka F, Kuribayashi T, Koyama T, Sakata K, Okayama A
  • Journal Title: Circ J Volume: 77(5) Pages: 1315-1325
  • DOI: 10.1253/circj.CJ-12-0982
  • Peer Reviewed
• [Journal Article] Concordance of CKD stages in estimation by the CKD-EPI equation and estimation by the MDRD equation in the Japanese general population : The Iwate KENCO Study (2013)
  • Author(s): Ohsawa M, Tanno K, Itai K,Tanivir Chowdhury Turin,Okamura T, Ogawa A, Ogasawara K, Fujioka T, Onoda T, Yoshida Y, Omama S, Ishibashi Y,Nakamura M, Makita S, Tanaka F, Kuribayashi T, Koyama T, Sakata K,Okayama A
  • Journal Title: Int J Cardiol Volume: 165(2) Pages: 377-379
  • DOI: 10.1016/j.ijcard.2012.08.025
• [Journal Article] 循環器予防とバイオマーカーBNPと心血管疾患:日本人コホート研究の重要性 (2013)
  • Author(s): 中村元行
  • Journal Title: 日本循環器予防学会誌 Volume: 48 Pages: 18-22
  • Peer Reviewed
• [Journal Article] Comparison of the incidence of acute decompensated heart failure before and after the major tsunami in Northeast Japan (2012)
  • Author(s): Nakamura M, Tanaka F, Nakajima S,HonmaM, Sakai T, Kawakami M, Endo H, Onodera M, Niiyama M, Komatsu T, Sakamaki K, Onoda T, Sakata K, Morino Y, Takahashi T, Makita S, Koyama T, Sakata K, Okayama A
  • Journal Title: Am J Cardiol Volume: 110(12) Pages: 1856-1860
  • DOI: 10.1016/j.amjcard.2012.08.020
  • Peer Reviewed
• [Journal Article] 震災時における発症増加の機序を織る震災と心不全 (2012)
  • Author(s): 肥田頼彦,中島悟史,森野禎浩,中村元行
  • Journal Title: Heart View Volume: 6(7) Pages: 708-713
  • Peer Reviewed
• [Journal Article] Serum C-Reactive Protein Levels and Death and Cardiovascular Events in Mild to Moderate Chronic Kidney Disease (2011)
  • Author(s): Koeda Y, Nakamura M, Tanaka F, Onoda T, Itai K. Ohsawa M. Makita S, Ishibashi Y, Koyama T, Yoshida Y, Omama S, Ogasawara K, Ogawa A, Kuribayashi T, Okayama A
  • Journal Title: Int Heart J Volume: 52(3) Pages: 180-184
  • DOI: 10.1536/ihj.52.180
  • Peer Reviewed
• [Presentation] HDL is a Significant Risk Marker to Predict Cardiovascular Events in Atrial Fibrillation with Low CHADS2 Score; A Community-based Study (2014)
  • Author(s): 佐藤権裕,田中文隆,瀬川利恵,高橋智弘,小野田敏行,大澤正樹,丹野高三,坂田清美,椚田房紀,小松隆,岡山明,中村元行
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京都
  • Year and Date: 20140300
• [Presentation] Framingham Risk Score, CRP, Urinary Albumin, and BNP : Which is the Best Predictor for Congestive Heart Failure in the General Population? (2014)
  • Author(s): 瀬川利恵,小野田敏行,田中文隆,板井一好,大澤正樹,丹野高三,坂田清美,川村和子,吉田雄樹,小笠原邦昭,岡山明,中村元行
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京都
  • Year and Date: 20140300
• [Presentation] Bradycardia is Associated with Future Cardiovascular Diseases and Death in Men from the General Population (2014)
  • Author(s): 蒔田真司,小野田敏行,大澤正樹,丹野高三,田中文隆,瀬川利恵,高橋智弘,佐藤権裕,坂田清美,吉田雄樹,岡山明,中村元行
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京都
  • Year and Date: 20140300
• [Presentation] A Longitudinal Survey of Blood Pressure of Tsunami Victims in Iwate after the Great East Japan Earthquake : RIAS Study (2014)
  • Author(s): 高橋智弘,新山正展,中島悟史,川上幹夫,長沼雄二郎,小野田敏行,坂田清美,蒔田真司,森野禎浩,中村元行
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京都
  • Year and Date: 20140300
• [Presentation] Increased Incidence of Sudden Unexpected Death after 2011 Earthquake and Tsunami Disaster in Northeast Japan : A Population-Based Study (2014)
  • Author(s): 新山正展,田中文隆,川上幹夫,長沼雄二郎,松本立也,西山理,伊藤智範,小野田敏行,坂田清美,中村元行
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京都
  • Year and Date: 20140300
• [Presentation] Impacts of Blood Pressure Levels are Different among Types of Cardiovascular Risk Factors : A Population-based Cohort Study (2014)
  • Author(s): 田中文隆,蒔田真司,小野田敏行,大澤正樹,丹野高三,大間々真一,板井一好,坂田清美,小笠原邦昭,岡山明,中村元行
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京都
  • Year and Date: 20140300
• [Presentation] Direct relationship between incidence of acute myocardial infarction and seismic intensity in the 2011 East earthquake and tsunami disaster : A population based study (2013)
  • Author(s): Tanaka F, Nakamura M
  • Organizer: American Heart Asociation
  • Place of Presentation: Dallas.USA
  • Year and Date: 20131100
• [Presentation] Increased Incidence of Sudden Death after 2011 Earthquake and Tsunami Disaster in Northeast Japan:A Population-Based Study (2013)
  • Author(s): Niiyama M, Tanaka F, Segawa T, Takahashi T, Sato K, Watanabe S, Honma M, Onoda T, Sakara K, Nakamura M
  • Organizer: 10^<th> International Congress on Coronary Artery Disease
  • Place of Presentation: Florence,Italy
  • Year and Date: 20131000
• [Presentation] 東日本大震災前後のたこつぼ型心筋症の発症調査 (2013)
  • Author(s): 中島悟史,酒井敏彰,松本立也,遠藤浩司,伊藤智範,森野禎浩,中村元行
  • Organizer: 第61回日本心臓病学会
  • Place of Presentation: 熊本市
  • Year and Date: 20130900
• [Presentation] 拡張障害心不全の発症率の経時的増加:地域ベースでの発症登録研究 (2013)
  • Author(s): 本間美穂,中村元行,西山理,高橋智弘,田中文隆,佐藤権裕,酒井敏彰,小野田敏行,坂田清美
  • Organizer: 第61回日本心臓病学会
  • Place of Presentation: 熊本市
  • Year and Date: 20130900
• [Presentation] 東日本大震災と急性心筋梗塞症および突然死、心不全発症との関連 (2013)
  • Author(s): 田中文隆,中島悟史,高橋智弘,新山正展,伊藤智範,遠藤浩司,川上幹夫,酒井敏彰,松本立也,小野田敏行,坂田清美,森野禎浩,中村元行
  • Organizer: 第19回日本心臓リハビリテーション学会
  • Place of Presentation: 仙台市
  • Year and Date: 20130700
• [Presentation] Usefulness of new staging system for predicting cardiovascular risk and all-cause death in chronic kidney disease : A validation study (2013)
  • Author(s): Koeda Y, Segawa T, Ohsawa M, Sakata K, Nakamura M
  • Organizer: 81th European Atherosclerosis Society Congress
  • Place of Presentation: Lyon,France
  • Year and Date: 20130600
• [Presentation] 大自然災害後の急性心筋梗塞症例と慢性心不全例の増加:発症ピークの相違について (2013)
  • Author(s): 新山正展,田中文隆,中島悟史,酒井敏彰,小野寺正幸,川上幹夫,遠藤浩司,伊藤智範,高橋智弘,中村元行
  • Organizer: 第110回日本内科学会
  • Place of Presentation: 東京都
  • Year and Date: 20130400
• [Presentation] Different trends in increased incidence of myocardial infarctio and heart failure after 2011Earthquake and Tsunami Disaster in Iwate (2013)
  • Author(s): 高橋智弘,田中文隆,新山正展,中島悟史,川上幹夫,遠藤浩司,酒井敏彰,小野寺正幸,佐久間雅文,小野田敏行,坂田清美,蒔田真司,森野禎浩,中村元行
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜市
  • Year and Date: 20130300
• [Presentation] The lipoprotein cholesterol ratio is a significant marker for predicting acute coronary syndrome in the japanese general population with normocholesterolemia (2013)
  • Author(s): 田中文隆,蒔田真司,小野田敏行,大澤正樹,丹野高三,板井一好,坂田清美,大間々真一,吉田雄樹,小笠原邦昭,岡山明,中村元行
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜市
  • Year and Date: 20130300
• [Presentation] Usefulness of plasma B-type Natriuretic Peptide as a marker in addition to traditional cardiovascular risk assessment for congestive heart failure (2013)
  • Author(s): 田中文隆,小野田敏行,大澤正樹,丹野高三,板井一好,坂田清美,大間々真一,蒔田真司,岡山明,吉田雄樹,小笠原邦昭,中村元行
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜市
  • Year and Date: 20130300
• [Presentation] Hyper-BNP-nemia is a Potent Biomarker for Predicting Cardiovascular events in the general population:Comparison to established modifiable cardiovascular risk factors (2013)
  • Author(s): 佐藤権裕,田中文隆,瀬川利恵,高橋智弘,酒井敏彰,西山理,松本立也,小野田敏行,坂田清美,岡山明,中村元行
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜市
  • Year and Date: 20130300
• [Presentation] Impact of Non-High-Density lipoprotein cholesterol on incidence of myocardial infarction and sudden cardiac death in male populations (2013)
  • Author(s): 蒔田真司,田中文隆,瀬川利恵,高橋智弘,佐藤権裕,小野田敏行,丹野高三,大澤正樹,坂田清美,吉田雄樹,岡山明,中村元行
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜市
  • Year and Date: 20130300
• [Presentation] Effect of the 2011 Tohoku Earthquake on the incidence of acute myocardial infarction and sudden death in iwate prefecture (2012)
  • Author(s): 田中文隆,小野田敏行,坂田清美,蒔田真司,中村元行
  • Organizer: 第16回日本心不全学会
  • Place of Presentation: 仙台市
  • Year and Date: 20121100
• [Presentation] 東日本大震災後の沿岸被災地域における急性循環器疾患の調査 (2012)
  • Author(s): 中島悟史,伊藤智範,酒井敏彰,松本立也,川上幹夫,遠藤浩司,小野田敏行,坂田清美,森野禎浩,中村元行
  • Organizer: 第109回日本内科学会
  • Place of Presentation: 京都市
  • Year and Date: 20120400
• [Presentation] Plasma B-type Natriuretic Peptide is useful for cardiovascular risk stratification in hypertensive patients with left ventricular hypertrophy (2012)
  • Author(s): 佐藤権裕,田中文隆,高橋智弘,瀬川利恵,中村元行,小野田敏行,板井一好,大澤正樹,坂田清美,岡山明
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡市
  • Year and Date: 20120300
• [Presentation] Predictive value of plasma B-type natriuretic peptide for ischemic stroke in women : Acommunity-based male longitudinal study (2012)
  • Author(s): 高橋智弘,田中文隆,瀬川利恵,佐藤権裕,小野寺正幸,小野田敏行,板井一好,大澤正樹,丹野高三,坂田清美,大間々真一,吉田雄樹,小川彰,石橋靖宏,蒔田真司,川村和子,岡山明,中村元行
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡市
  • Year and Date: 20120300
• [Presentation] Albuminuria is higher population -attributable risk for cardiovascular events than impaired filtration function in the general population (2012)
  • Author(s): 田中文隆,小野田敏行,瀬川利恵,佐藤権裕,高橋智弘,大澤正樹,蒔田真司,丹野高三,板井一好,坂田清美,岡山明,中村元行
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡市
  • Year and Date: 20120300
• [Presentation] 血漿BNP濃度はメタボリック症候群患者の心血管疾患発症リスクの層別化に有効である (2011)
  • Author(s): 瀬川利恵,田中文隆,板井一好,大澤正樹,丹野高三,坂田清美,川村和子,岡山明,中村元行
  • Organizer: 第84回日本内分泌学会
  • Place of Presentation: 神戸市
  • Year and Date: 20110400