Multicenter registry for acute decompensated heart failure

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Keio University
• Principal Investigator: YOSHIKAWA Tsutomu 慶應義塾大学, 医学部, 共同研究員 (20174906)
• Co-Investigator(Kenkyū-buntansha): KOHSAKA Shun 慶應義塾大学, 医学部, 特任講師 (30528659)
• Project Period (FY): 2011 – 2013
• Keywords: 急性心不全 / バイオマーカー / データベース / 医療の質

Research Abstract

Therapeutic strategies for heart failure has been almost all established according to the accumulating evidences based upon numerous large-scale clinical trials. However, these data are based upon relatively young patients with no comorbidity that are quite different from real world heart failure patients. We cannot necessarily apply evidence-based approach to elderly patients who have multilple comorbidities. In this study, we attempted to create large-scale prospective database on real world heart failure patients to clarify clinical problems to be solved. We enrolled approximately 1500 patients with decompensated heart failure who were hospitalized to 3 major teaching hospitals from 2011 to 2013. We analyzed the database from multiple points of view and reported the results at many scientific meetings, and published couples of papers.

Research Products

• [Journal Article] Characterization of predictors of in-hospital cardiac complications of takotsubo cardiomyopathy : multi-center registry from Tokyo CCU Network (2014)
  • Author(s): Murakami T, Yoshikawa T, Maekawa Y, Ueda T, Isogai T, Konishi Y, Sakata K, Nagao K, Yamamoto T, Takayama M
  • Journal Title: J Cardiol Volume: 63 Pages: 269-73
  • DOI: 10.1016/j.jjcc.2013.09.003
  • Peer Reviewed
• [Journal Article] Discharge heart rate and future events among Japanese patients with acute heart failure receiving beta-blocker therapy (2013)
  • Author(s): Oshima K, Kohsaka S, Koide K, Nagatomo Y, Nagai T, Endo Y, Yoshikawa T, Fukuda K
  • Journal Title: World J Cardiovasc Dis Volume: 3 Pages: 159-67
  • DOI: 10.4236/wjcd.2013
  • Peer Reviewed
• [Journal Article] The prognostic implication of high-sensitivity C-reactive protein in patients with established cardiomyopathy (2013)
  • Author(s): Matsumoto K, Kohsaka S, Fukuda K
  • Journal Title: Am Heart J Volume: 165 Pages: e17
  • DOI: 10.1016/j.ahj.2013.02.001
  • Peer Reviewed
• [Journal Article] Minimal dose for effective clinical outcome and predictive factors for responsivensee to carvedilol : Japanese chronic heart failure (J-CHF) study (2013)
  • Author(s): Okamoto H, Hori M, Matsuzaki M, Tsutsui H, Yamazaki T, Nagai R, Yoshikawa T, Fujio Y, None S, Azuma J, Izumi T, Ohashi Y, Kitabatake A
  • Journal Title: Int J Cardiol Volume: 164 Pages: 238-44
  • DOI: 10.1016/j.ijcard.2012.11.051
  • Peer Reviewed
• [Journal Article] Steady-state levels of troponin and brain natriuretic peptide for prediction of long-term outcome after acute heart failure with or without stage 3 to 4 chronic kidney disease (2012)
  • Author(s): Endo Y, Kohsaka S, Nagai T, Koide K, Takahashi M, Nagatomo Y, Oshima K, Miyata H, Fukuda K, Yoshikawa T
  • Journal Title: British Journal Med & Med Res Volume: 2 Pages: 490-500
  • URL: http://www.sciencedomain.org
  • Peer Reviewed
• [Journal Article] Association between prehospital time interval and short-term outcome in acute heart failure patients (2011)
  • Author(s): Takahashi M, Kohsaka S, Yoshikawa T, Takagi A, Harada K, Miyamoto T, Sakai T, Nagao K, Sato N, Takayama M
  • Journal Title: J Card Fail Volume: 17 Pages: 742-7
  • DOI: 10.1016/j.cardfail.2011.05.005
  • Peer Reviewed
• [Presentation] Impaired Renal Function Predicts Adverse Clinical Outcomes in Relation to Abnormal Erythropoiesis in Patients with Acutely Decompensated Heart Failure (2014)
  • Author(s): Izumi Y, Yagawa M, Mahara K, Tomoike H, Kohsaka S, Inohara T, Goda A, Yoshikawa T
  • Organizer: 78^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
  • Year and Date: 2014-03-23
• [Presentation] The Prognostic Impact of Hepatic Dysfunction Based on the MELD-XI Scoring System in Patients with Acute Decompensated Heart Failure (2014)
  • Author(s): Inohara T, Kohsaka S, Shiraishi Y, Sawano M, Yagawa M, Mahara K, Goda A, Yoshikawa T, Fukuda K
  • Organizer: 78^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
  • Year and Date: 2014-03-22
• [Presentation] Is Plasma Volume Reduction Related to Worsening Renal Function in Heart Failure with/without Preserved Ejection Fraction? (2014)
  • Author(s): Takei M, Kohsaka S, Inohara T, Shiraishi Y, Sawano M, Goda A, Yoshikawa T, Fukuda K
  • Organizer: 78^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
  • Year and Date: 2014-03-22
• [Presentation] Constructing a successful multicenter registry in Japan : overcoming the hurdles with internet technology and skilled CRCs (2014)
  • Author(s): Ueda I, Kohsaka S, Kawamura A, Sueyoshi K, Noma S, Suzuki M, Momiyama Y, Nakagawa S, Koyama T, Okada Y, Ishikawa S, Ohki T, Takahashi T, Nishi Y, Nakamura I, Takagi S, Negishi K, Matsubara T, Inoue S, Fukuda K
  • Organizer: 78^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
  • Year and Date: 2014-03-22
• [Presentation] Difference in the Impact of Left Atrium Size by Presence/Absence of LV Systolic Dysfunction among Acute Heart Failure Patients (2014)
  • Author(s): Uesugi Y, Goda A, Inohara T, Shiraishi Y, Yagawa M, Mahara M, Matsushita K, Kohsaka S, Yoshikawa T, Sato T, Yoshino H
  • Organizer: 78^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
  • Year and Date: 2014-03-21
• [Presentation] Clinical outcomes of heart failure with preserved and reduced ejection fraction who are hospitalized with acute decompensated heart failure (2013)
  • Author(s): Yagawa M, Yoshikawa T, Izumi Y, Mahara K, Kohsaka S, Takayama M, Umemura J, Sumiyoshi T, Tomoike H
  • Organizer: 17^<th> Annual Scientific Session of Japanese Heart Failure Society Meeting
  • Place of Presentation: Saitama
  • Year and Date: 2013-11-30
• [Presentation] 拡張型心筋症に対する免疫吸着療法 (2013)
  • Author(s): 吉川勉
  • Organizer: 第17回日本心不全学会教育講演7
  • Place of Presentation: さいたま
  • Year and Date: 2013-11-29
• [Presentation] Utilization of clinical scenario in real world acutely decompensated heart failure patients (2013)
  • Author(s): Ishiguro M, Goda A, Inohara T, Yagawa M, Makhara K, Kohsaka S, Yoshikawa T, Satoh T, Yoshino H
  • Organizer: 17^<th> Annual Scientific Session of Japanese Heart Failure Society Meeting
  • Place of Presentation: Saitama
  • Year and Date: 2013-11-28
• [Presentation] Characteristics of the elderly acute heart failure patient : data from multicenter AHF registry in Tokyo metropolitan area (2013)
  • Author(s): Funabashi S, Goda A, Inohara T, Yagawa M, Mahara K, Kohsaka S, Yoshikawa T, Satoh T, Yoshino H
  • Organizer: 17^<th> Annual Scientific Session of Japanese Heart Failure Society Meeting
  • Place of Presentation: Saitama
  • Year and Date: 2013-11-28
• [Presentation] Impaired renal function predicts poor shor- and long-term clinical outcomes in relation ot anemia in acutely decompensated heart failure (2013)
  • Author(s): Izumi Y, Yoshikawa T, Yagawa M, Mahara K, Kohsaka S, Takayama M, Umemura J, Sumiyoshi T, Tomoike H
  • Organizer: 17^<th> Annual Scientific Session of Japanese Heart Failure Society Meeting
  • Place of Presentation: Saitama
  • Year and Date: 2013-11-28
• [Presentation] Presence of atrial fibrillation does not affect long-term prognosis in patients who are hospitalizaed with acute decompensated heart failure (2013)
  • Author(s): Yagawa M, Yoshikawa T, Izumi Y, Mahara K, Kohsaka S, Takayama M, Umemura J, Sumiyoshi T, Tomoike H
  • Organizer: 17^<th> Annual Scientific Session of Japanese Heart Failure Society Meeting
  • Place of Presentation: Saitama
  • Year and Date: 2013-11-28
• [Presentation] 拡張型心筋症における自己免疫機序 (2013)
  • Author(s): 吉川勉
  • Organizer: 第17回日本適応医学会シンポジウムII「心血管系における適応とその破綻」
  • Place of Presentation: さいたま
  • Year and Date: 2013-06-29
• [Presentation] Unique Characteristics of Acute Heart Failure Management in Japan and Its Impact on Long-term Outcome (2013)
  • Author(s): Kohsaka S, Yoshikawa T, Fukuda K
  • Organizer: Japanse Circulation Society Meeting 2013, Plenary Session 3"To Improve Outcomes of Acute Heart Failure Patients : Lessons from Asian and Western Registries"
  • Place of Presentation: Yokohama
  • Year and Date: 2013-03-16
• [Presentation] Significance of the Presence of Atrial Fibrillation in Patients who are Hospitalized with Acute Decompensated Heart Failure (2013)
  • Author(s): Yagawa M, Yoshikawa T, Izumi Y, Mahara K, Kohsaka S, Takayama M, Umemura J, Sumiyoshi T, Tomoike H
  • Organizer: Japanese Circulation Society Meeting 2013
  • Place of Presentation: Yokohama
  • Year and Date: 2013-03-16
• [Presentation] Association between baseline physical findings and persistently elevated biomarker level acute heart failure (2012)
  • Author(s): Negi S, Kohsaka S, Koide K, Nagatomo Y, Motoda H, Kimura K, Sano M, Yoshikawa T, Fukuda K
  • Organizer: 16^<th> Japanese Heart Failure Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2012-12-02
• [Presentation] Early vs. late reverse remodeling in patients with cardiomyopathy after acute decompensation (2012)
  • Author(s): Banno A, Kohsaka S, Kimura K, Koide K, Motoda H, Inohara T, Sano M, Yoshikawa T, Fukuda K
  • Organizer: 16^<th> Japanese Heart Failure Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2012-12-01
• [Presentation] Comparison between heart failure with preserved and reduced ejection fraction who are hospitalized with acute decompensated heart failure (2012)
  • Author(s): Yagawa M, Yoshikawa T, Mahara K, Kohsaka S, Tomoike H
  • Organizer: 16^<th> Japanese Heart Failure Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2012-11-30
• [Presentation] β1アドレナリン受容体に対する自己抗体の存在はβ遮断薬の有効性を予測する:J-CHF試験サブスタデイより (2012)
  • Author(s): 吉川勉、長友祐司、馬場彰泰、岡本洋、堀正二、北畠顕
  • Organizer: 第60回日本心臓病学会シンポジウム1「循環器疾患と交感神経系」
  • Place of Presentation: 金沢
  • Year and Date: 2012-09-14
• [Presentation] Impact of atrial fibrillation in advanced heart failure patients admitted for acute decompensation : perspectives from single center cardiomyopathy registry (2012)
  • Author(s): Kohsaka S, Takatsuki S, Yoshikawa T, Fukuda K
  • Organizer: 76^<th> Annual Scientific Meeting of the Japanese Circulation Society, Plenary Session"Total Arrhthmic Management for Advanced Heart Failure"
  • Place of Presentation: Fukuoka
  • Year and Date: 2012-03-17
• [Presentation] Stress cardiomyopathy in the Tokyo urban district in Japan (2012)
  • Author(s): Yoshikawa T, Mahara K, Maekawa Y, Ueda T, Isogai T, Konishi Y, Sakata K, Nagao K, Yamamoto T, Takayama M
  • Organizer: 76^<th> Annual Scientific Meeting of the Japanese Circulation Society, Symposium #22"Update in the Diagnosis and Treatment for Secondary Cardiomyopathy"
  • Place of Presentation: Fukuoka
  • Year and Date: 2012-03-16
• [Presentation] Immunoadsorption therapy for patients with refractory heart failure due to dilated cardiomyopathy (2011)
  • Author(s): Yoshikawa T, Nagatomo Y, Maekawa Y, Yoshizawa A, Monkawa T, Hayashi M, Wakabayashi Y, Akaishi M, Baba A
  • Organizer: 75^<th> Japanese Circulation Society Meeting, Focus Session #2"Recent Advancements in Non-pharmacologic Therapy for Heart Failure, part II. Current Status and Future Direction of Severe Heart Failure"
  • Place of Presentation: Yokohama
  • Year and Date: 2011-08-04
• [Presentation] Recent Advances in the management of acutely decompensated failure : insight from Tokyo CCU network database (2011)
  • Author(s): Kohsaka S, Sakai T, Takagi A, Harada K, Miyamoto T, Miyata H, Yoshikawa T, Nagao K, Satoh N, Takayama M
  • Organizer: 75^<th> Japanese Circulation Society Meeting, Symposium #8"Therapeutic Approach for Acutely Decompensated Heart Failure"
  • Place of Presentation: Yokohama
  • Year and Date: 2011-08-04