2013 Fiscal Year Final Research Report
Significance of Lp(a) cholesterol in the risk determination of atherosclerosis
| Project/Area Number |
23591066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHODA Toru 東京慈恵会医科大学, 医学科, 助教 (80266634)
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| Project Period (FY) |
2011 – 2013
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| Keywords | Lp(a)コレステロール / 動脈硬化 / バイオマーカー / MMP-2 / 血管内皮膚細胞 |
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| Research Abstract |
HPLC lipoprotein analysis showed that in 212 male subjects without cardiovascular disease Lp(a)-C did not correlate with LDL-C while Lp(a)-C correlated positively with IDL-C, VLDL-C, chylomicron-C, but inversely correlated with HDL-C. Framingham Risk Score for atherosclerosis significantly provided a positive correlation to non-HDL-C but a modest correlation to Lp(a)-C. In the basic experiments to establish the study for Lp(a) effects on secretion of MMP-2, a destabilizing factor of atherosclerosis, from vascular endothelial cells, angiotensin 2 (Ang2) enhanced MMP-2, and the Ang2 receptor blocker cancelled that, and thereby it was found that Ang2 could enhance MMP-2 through Ang2 receptors. Although Lp(a) also may have certain potential to enhance MMP-2, its reproducibility and its mechanisms should be revealed. Therefore, Lp(a)-C and MMP-2 may be expected to play a role in biomarkers of cardiovascular disease.
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[Journal Article] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene2013
Author(s)
Takase S, Osuga J, Fujita H, Hara K, Sekiya M, Igarashi M, Takanashi M, Takeuchi Y, Izumida Y, Ohta K, Kumagai M, Nishi M, Kubota M, Masuda Y, Taira Y, Okazaki S, Iizuka Y, Yahagi N, Ohashi K, Yoshida H, et al.
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Journal Title
J Atheroscler Thromb
Volume: 20
Pages: 481-93
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