2013 Fiscal Year Final Research Report
A study of the effect that deoxyribonucrease I induces apotosis in cardiac diseases
| Project/Area Number |
23591067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YASUDA Toshihiro 福井大学, 医学部, 教授 (80175645)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 酸化ストレス / 冠れん縮 / 一過性心筋虚血 / ニトロチロシン |
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| Research Abstract |
We could not find out that deoxyribonuclease I induce apoptosis in cardiac diseases. Then, we evaluated whether nitrotyrosin (NT), a marker of oxidative stress, would elevate after vasospasm induced achtylcholine provocation test in patinets with vasospastic angina pectoris (VSAP). The serum NT levels significantly increased after coronary vasospasm induced by the test, suggensting that serum NT could be a biomarker of transient myocardial ischemia and could contribute to the development of VSAP.
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[Journal Article] Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm2014
Author(s)
Tanabe K, Kawai Y, Kitayama M, Akao H, Ishida R, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Watanabe M, Tsuchiya T, Kimura H, Yoshida K, Kajinami K
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Journal Title
Journal of Cardiology
Volume: (in press)
Peer Reviewed
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