Body-surface QRS integral mapping predicts response to cardiac resynchronization therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591071
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: International University of Health and Welfare (2013-2014); Kurume University (2011-2012)
• Principal Investigator: INAGE Tomohito 国際医療福祉大学, 保健医療学部, 講師 (70360287)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 心臓再同期療法 / 慢性心不全

Outline of Final Research Achievements

Cardiac resynchronization therapy (CRT) has been shown to improve clinical function of heart failure. However, clinical trials show that up to 30% of patients receiving CRT may not benefit from this therapy. Body-surface QRS integral mapping has been shown to be a useful noninvasive method to assess the ventricular depolarization. In this study, we evaluated whether QRS integral mapping is useful to identify patients who may benefit from CRT.
Body-surface QRS integral mapping was obtained after CRT from twenty five patients.11 patients had normal dipolar map pattern whereas 14 patients had an abnormal dipolar map pattern. No patient of normal dipolar map pattern developed HF. Five patients of 14 patients who had an abnormal dipolar map pattern were hospitalized for worsening HF. Thus, abnormal dipolar map pattern was associated with a higher incidence of worsening HF after CRT(p<0.05).Body-surface QRS integral mapping may be a useful diagnostic tool to identify response to CRT.

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