Comprehensive And Therapeutic Strategy for Heart Failure Via Dipepidylpepidase-4 (DPP-4) Axis.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591080
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Nagoya University
• Principal Investigator: BANDO Yasuko K. (暮石 泰子) 名古屋大学, 医学部附属病院, 講師 (60452190)
• Co-Investigator(Kenkyū-buntansha): MUROHARA Toyoaki 名古屋大学, 医学系研究科, 教授 (90299503) ; HIRASHIKI Akihiro 名古屋大学, 医学系研究科, 寄附講座助教 (10418741) ; CHENG Xianwu 名古屋大学, 医学系研究科, 特任准教授 (30378228)
• Project Period (FY): 2011 – 2013
• Keywords: 分子心臓病理学 / 糖尿病性心筋症

Research Abstract

Heart failure caused by diabetes has been designated as diabetic cardiomyopathy and the underlying pathophysiology remains uncertain. Our group has focused and clarified the molecular mechanisms underlying diabetic cardiomyopathy both in preclinical and clinical settings and has found the primary role of incretin, particularily glucagon-like peptide (GLP-1), and its proteolytic regulator dipeptidyl peptidase-4 (DPP4) in pathogenesis of microvasculopathy and mitochondrial remodeling observed in diabetic cardiomyopathy. Moreover, we have recently obtained important clues implicating the potent role of incretine-insulin axis in diagnosis, thepeutic intervention, and prevention of heart failure. We thus aimed to establish the comprehensive system for managing heart failure via modulating incretine-insulin axis to reduce mortality and ameliorate quality of life.

Research Products

• [Journal Article] Diabetes-Related Heart Failure - Does Diabetic Cardiomyopathy Exist?– (2014)
  • Author(s): Bando YK (corresponding author) and Murohara T.
  • Journal Title: Circ J. Volume: 78(3)(invited review) Pages: 576-83
  • Peer Reviewed
• [Journal Article] Left ventricular diastolic dysfunction is associated with cerebral white matter lesions (leukoaraiosis) in elderly patients without ischemic heart disease and stroke (2014)
  • Author(s): Shimizu A, Sakurai T, Mitsui T, Miyagi M, Nomoto K, Kokubo M, Bando YK, Murohara T, Toba K.
  • Journal Title: Geriatr Gerontol Int. Volume: Suppl2 Pages: 71-6
  • Peer Reviewed
• [Journal Article] Usefulness of serum cardiac troponins T and I to predict cardiac molecular changes and cardiac damage in patients with hypertrophic cardiomyopathy (2013)
  • Author(s): Okamoto R, Hirashiki A, Cheng XW, Yamada T, Shimazu S, Shinoda N, Okumura T, Takeshita K, Bando YK, Kondo T, Murohara T.
  • Journal Title: Int Heart J. Volume: 54(4) Pages: 202-6
  • Peer Reviewed
• [Journal Article] Glucagon-like peptide-1 receptor activation reverses cardiac remodeling via normalizing cardiac steatosis and oxidative stress in type 2 diabetes (2013)
  • Author(s): Monji A, Mitsui T, Bando YK (corresponding author), Aoyama M, Shigeta T, Murohara T.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 305(3) Pages: H295-304
  • Peer Reviewed
• [Journal Article] Dipeptidyl Peptidase-4 Modulates Left Ventricular Dysfunction in Chronic Heart Failure via Angiogenesis-Dependent and-Independent Actions (2012)
  • Author(s): Shigeta T, Aoyama M, Bando YK, (corresponding author), Monji A, Mitsui T, Takatsu M, Cheng XW, Okumura T, Hirashiki A, Nagata K, Murohara T.
  • Journal Title: Circulation Volume: 126(15) Pages: 1838-51
  • Peer Reviewed
• [Presentation] Dipeptidylpeptidase-4 activation accelerates cardiac fibrosis via MMP2/TIMP2 axis in diabetic heart (2013)
  • Author(s): 青山盛彦, 坂東泰子
  • Organizer: 第77回日本循環器学会.Featured Research Session066
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2013-03-16
• [Presentation] Circulating DPP4 activity presumably serves as a surrogate for systolic heart failure and diabetes (2013)
  • Author(s): 三井統子、坂東泰子
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2013-03-16
• [Presentation] 新しい抗糖尿病薬は循環器疾患予防に貢献できるか? (2013)
  • Author(s): 坂東泰子
  • Organizer: 第77回日本循環器学会シンポジウム19
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2013-03-15
• [Presentation] 糖尿病における心血管病の特徴と対策 (2012)
  • Author(s): 坂東泰子
  • Organizer: 第76回日本循環器学会シンポジウム18
  • Place of Presentation: 福岡国際会議場、福岡
  • Year and Date: 2012-03-17