2013 Fiscal Year Final Research Report
Elucidation of role of fatty acid-binding protein in vascular endothelial function and blood pressure control
| Project/Area Number |
23591106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脂肪酸結合タンパク / 血管内皮 / 血圧 |
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| Research Abstract |
Fatty acid-binding protein 4 is expressed in both adipcoytes and macrophages and plays an important role in many aspects of metabolic syndrome. Here we investigated the role of secreted form and ectopic expression of FABP4 on blood pressure regulation. Serum FABP4 level was significantly higher in essential hypertensives than in normotensives. Serum FABP4 level was positively and independently correlated with blood pressure and insulin resistance. Angiotensin II receptor blockers significantly decreased FABP4 level in hypertensives. FABP4-deficient mice protected from blood pressure elevation. Expression of FABP4 was related to increased inflammatory markers. Further understanding of role of FABP4 on blood pressure and endothelial function will enable the development of new therapeutic strategies for hypertension.
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[Journal Article] Adipocyte lipid chaperone aP2 is a secreted adipokine regulating hepatic glucose production2013
Author(s)
Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS
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Journal Title
Cell Metab
Volume: 17
Pages: 768-778
DOI
Peer Reviewed
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