2013 Fiscal Year Final Research Report
Characterization of ARIA that regulates angiogenesis and vasculogenesis: its therapeutic application to ischemic diseases
| Project/Area Number |
23591107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KOJI IKEDA 京都府立医科大学, 医学(系)研究科(研究院), 助教 (90423871)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血管新生 / 血管内皮細胞 / PI3K / Akt |
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| Research Abstract |
We have identified a novel gene termed ARIA that regulates angiogenic functions in endothelial cells. Here, we further characterized its function by using ARIA-deficient mice. ARIA-deficient mice demonstrated substantially enhanced neovessel formation comparing to WT mice assessed by hindlimb ischemia model. Moreover, we revealed that enhanced PI3K/Akt signaling in both endothelial cells and endothelial progenitor cells is attributable to the increased neovessel formation in ARIA-deficient mice. Also, we fond a small compound that potentially inhibit ARIA function by in silico screening. Inhibition of ARIA is a new therapeutic approach to treat ischemic diseases.
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