2013 Fiscal Year Final Research Report

Associations of TF and F7 with pathogenesis of asthma and COPD

Research Project

Project/Area Number	23591110
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Respiratory organ internal medicine
Research Institution	Hokkaido University
Principal Investigator	KONNO Satoshi 北海道大学, 大学病院, 講師 (20399835)
Co-Investigator(Kenkyū-buntansha)	ISADA Akira 北海道大学, 北海道大学病院, 特任助教 (80374289) NASUHARA Yasuyuki 北海道大学, 北海道大学病院, 准教授 (30322811)
Project Period (FY)	2011 – 2013
Keywords	閉塞性肺疾患
Research Abstract	Levels of tissue factor(TF) and factor7 in BALF were signnificantly increased after OVA challenge in two murine models of asthma (acute and chronic models). Intraperitoneal administration of TF-factor7 inhibitor significantly decreased the number of eosinophils in BALF, OVA-IgE levels in serum and bronchial hyperresponsiveness in these moedels, suggesting the potential of TF-factor7 as a novel therapeutic target for asthma treatment. In genetic studies, we conducted case (asthma)-control studies for several genes related with coagulation cascade, including TF,F2R,CC16 and CAT and significant associations of several SNPs in these genes and asthma were identified.