• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Roles of Th9 cells in the development of allergic glanulomatous angitis and asthma

Research Project

  • PDF
Project/Area Number 23591113
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionChiba University

Principal Investigator

HIROSE KOICHI  千葉大学, 医学(系)研究科(研究院), 准教授 (90400887)

Co-Investigator(Kenkyū-buntansha) TAKATORI Hiroaki  千葉大学, 医学部附属病院, 助教 (30568225)
Co-Investigator(Renkei-kenkyūsha) NAKAJIMA Hiroshi  千葉大学, 大学院医学研究院, 教授 (00322024)
SUTO Akira  千葉大学, 大学院医学研究院, 特任准教授 (50447306)
IKEDA Kei  千葉大学, 医学部附属病院, 助教 (10456014)
Project Period (FY) 2011 – 2013
KeywordsIL-25 / Th9細胞 / 肺動脈周囲炎 / 血管リモデリング
Research Abstract

Recent studies have shown that prplonged Th2-type immune inflammation in the lung induces pulmonary arterial remodeling. However, roles of IL-25, which promotes Th2-type inflammation, in the development of pulmonary arterial remodeling remain unknown. In this study, we evaluated the role of IL-25 in the development of pulmonary arterial remodeling. Repeated OVA inhalation induced pulmonary arterial wall thickening and the expression of IL-25 and RELMa mRNA in the lung in OVA-sensitized mice. Injection of neutralizing anti-IL-25 antibody inhibited OVA-induced pulmonary arterial wall thickening and RELMa expression in the lung. CC10 IL-25 mice but not CC10 IL-25 NKT-/- mice spontaneously developed pulmonary arterial wall thickening and RELMa expression in the lung at 6 months of age. These results shows that prolonged expression of IL-25 in the lung induces pulmonary arterial wall thickening by NKT cell-dependent mechanisms.

  • Research Products

    (28 results)

All 2014 2013 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (13 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Dectin-2 promotes house dust mite-induced Th2 and Th17 cell differentiation and allergic airway inflammation in mice2014

    • Author(s)
      Norimoto A, Hirose K, Iwata A, Tamachi T, Yokota M, Takahashi K, Saijo S, Iwakura Y, Nakajima H
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Ultrasonographic assessment predicts relapse after discontinuation of biological agents in patients with rheumatoid arthritis in clinical remission - high predictive values of total gray-scale and power Doppler scores which represent residual synovial inflammation before discontinuation2014

    • Author(s)
      Iwamoto T, Ikeda K, Hosokawa J, Yamagata M, Tanaka S, Norimoto A, Sanayama Y, Nakagomi D, Takahashi K, Hirose K, Sugiyama T, Sueishi M, Nakajima H
    • Journal Title

      Arthritis Care Res

      Volume: (in press)

    • DOI

      10.1002/acr.22303

    • Peer Reviewed
  • [Journal Article] Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity2014

    • Author(s)
      Iwata A, Kawashima S, Kobayashi M, Kawashima H, Suto A, Hirose K, Nakayama T, Nakajima H
    • Journal Title

      Int Immunol

      Volume: 26 Pages: 103-14

    • DOI

      10.1093/intimm/dxt047

    • Peer Reviewed
  • [Journal Article] Pre-dinner administration increases the efficacy connective tissue disease patients2013

    • Author(s)
      Iwata A, Ikeda K, Hirose K, Takatori H, Takahashi K, Suzuki Y, Tanaka S, of proton pump inhibitors on refractory GERD symptoms in Suto A, Nakajima H
    • Journal Title

      Mod Rheumatol

      Volume: 23 Pages: 357-64

    • DOI

      10.1007/s10165-012-0662-5

    • Peer Reviewed
  • [Journal Article] Interleukin- 25 induces pulmonary arterial remodeling via natural killer T cell- dependent mechanisms2013

    • Author(s)
      Kawashima S, Hirose K, Takahashi K, Tamachi T, Ikeda K, Tokoyoda K, Nakayama T, Nakajima H
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 161(S2) Pages: 118-24

    • DOI

      10.1159/000350379

    • Peer Reviewed
  • [Journal Article] Role of IL-22 in allergic airway inflammation2013

    • Author(s)
      Hirose K, Takahashi K, Nakajima H
    • Journal Title

      J Allergy

      Volume: 2013 Pages: 260518

    • DOI

      10.1155/2013/260518

    • Peer Reviewed
  • [Journal Article] Roles of IL-17 family cytokines in allergic airway inflammation2013

    • Author(s)
      Nakajima H, Hirose K
    • Journal Title

      Arerugi

      Volume: 62 Pages: 822-826

    • URL

      http://jja.jsaweb.jp/2013/062070822e.html

    • Peer Reviewed
  • [Journal Article] Clinical characteristics of Nocardia infection in patients with rheumatic diseases2013

    • Author(s)
      Yamagata M, Hirose K, Ikeda K, Nakajima H
    • Journal Title

      Clin Dev Immunol

      Volume: 2013 Pages: 818654

    • DOI

      10.1155/2013/818654

    • Peer Reviewed
  • [Journal Article] Tumor suppresser p53 inhibits systemic autoimmune diseases by inducing regulatory T cells2013

    • Author(s)
      Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, Minamino T, Hirose K, Nakajima H
    • Journal Title

      J Immunol

      Volume: 191 Pages: 3614-23

    • DOI

      10.4049/jimmunol.1300509

    • Peer Reviewed
  • [Journal Article] Roles of CRTH2+ CD4+ T Cells in Immunoglobulin G4-Related Lacrimal Gland Enlargement2012

    • Author(s)
      Saito Y, Kagami S, Kawashima S, Takahashi K, Ikeda K, Hirose K, Oshitari T, Yamamoto S, Okamoto Y, Nakajima H
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 158 Pages: 42-46

    • DOI

      10.1159/000337761

    • Peer Reviewed
  • [Journal Article] β- glucan curdlan induces IL-10- producing CD4^+ T cells and inhibits allergic airway inflammation2012

    • Author(s)
      Kawashima S, Hirose K, Iwata A, Takahashi K, Ohkubo A, Tamachi T, Ikeda K, Kagami S, Nakajima H
    • Journal Title

      J Immunol

      Volume: 189 Pages: 5713-21

    • DOI

      10.4049/jimmunol.1201521

    • Peer Reviewed
  • [Journal Article] Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas- independent liver injury in MRL- lpr/lpr mice2011

    • Author(s)
      Oya Y, Watanabe N, Owada T, Oki M, Ikeda K, Suto A, Kagami S, Hirose K, Kishimoto T, Nakajima H
    • Journal Title

      Int Immunol

      Volume: 23 Pages: 335-44

    • DOI

      10.1093/intimm/dxr017

    • Peer Reviewed
  • [Journal Article] IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation2011

    • Author(s)
      Takahashi K, Hirose K, Kawashima S, Niwa Y, Wakashin H, Iwata A, Tokoyoda K, Renauld JC, Iwamoto I, Nakayama T, Nakajima H
    • Journal Title

      J Allergy Clin Immunol

      Volume: 128 Pages: 1067-76

    • DOI

      10.1016/j.jaci.2011.06.018

    • Peer Reviewed
  • [Presentation] Tumore suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells2013

    • Author(s)
      Takatori H, Suzuki K, Yokato M, Suto A, Hirose K, Nakajima H
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      千葉
    • Year and Date
      20131211-13
  • [Presentation] チリダニ誘発性アレルギー性気道炎症発症における真菌認識機構Dectin-2の役割2013

    • Author(s)
      大久保綾子、廣瀬晃一、西城忍、岩倉洋一郎、中島裕史
    • Organizer
      第63回日本アレルギー学会秋季学術集会
    • Place of Presentation
      東京
    • Year and Date
      20131128-30
  • [Presentation] アレルギー性気道炎症における樹状細胞の新たな役割2013

    • Author(s)
      廣瀬晃一、川島沙紀、中島裕史
    • Organizer
      第25回日本アレルギー学会春季臨床大会
    • Place of Presentation
      横浜
    • Year and Date
      20130511-12
  • [Presentation] スエヒロタケ(Schizophyllum commune)特異的IgE抗体測定ELISA法による喘息患者における感作率の検討2013

    • Author(s)
      廣瀬晃一、豊留孝仁、亀井克彦、岩本逸夫、中島裕史
    • Organizer
      第25回日本アレルギー学会春季臨床大会
    • Place of Presentation
      横浜
    • Year and Date
      20130511-12
  • [Presentation] FDG-PET/CTが病勢評価に有用であった炎症性大動脈瘤の1例2013

    • Author(s)
      高取宏昌、細川淳一、山形美絵子、牧田荘平、池田啓、廣瀬晃一、石坂透、松宮護郎、中島裕史
    • Organizer
      第25回日本アレルギー学会春季臨床大会
    • Place of Presentation
      横浜
    • Year and Date
      20130511-12
  • [Presentation] 当院におけるチャーグ・ストラウス症候群の臨床的検2013

    • Author(s)
      山形美絵子、眞山快枝、池田啓、廣瀬晃一, 中島裕史
    • Organizer
      第25回日本アレルギー学会春季臨床大会
    • Place of Presentation
      横浜
    • Year and Date
      20130511-12
  • [Presentation] Spontaneous development of psoriasis- like skin diseases in T-bet/Stat6- double deficient mice2012

    • Author(s)
      Tamachi T, Takatori H, Kawashima H, Nakagomi D, Hirose K, Nakajima H
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20121205-07
  • [Presentation] IL-25はNKT細胞を介して肺動脈周囲の炎症と肺動脈平滑筋の増生を誘発する2012

    • Author(s)
      川島沙紀、廣瀬晃一、玉地智宏、池田啓, 鈴木浩太郎、中島裕史
    • Organizer
      第62回日本アレルギー学会秋季学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20121129-1201
  • [Presentation] curdlanはIL-10産生性T細胞を誘導し、アレルギー性気道炎症を抑制する2012

    • Author(s)
      川島沙紀、廣瀬晃一、岩田有史、高橋健太郎、加々美新一郎、中島裕史
    • Organizer
      第62回日本アレルギー学会秋季学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20121129-1201
  • [Presentation] 膠原病治療中に生じたノカルジア感染症の臨床的検討2012

    • Author(s)
      山形美絵子、田中繁、中込大樹、岩田有史、池田啓、須藤明、加々美新一郎、廣瀬晃一, 中島裕史
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20120426-28
  • [Presentation] IL-25は気道上皮細胞によるIL-25産生を抑制しアレルギー性気道炎症を制御する2011

    • Author(s)
      高橋健太郎、廣瀬晃一、川島沙紀、丹羽祐輔、若新英史、小林芳久、常世田孝司、中山俊憲、谷口正実、秋山一男
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      20111110-12
  • [Presentation] IgG4関連涙腺腫脹症例におけるPGD2-CRTH2経路の役割の解析2011

    • Author(s)
      加々美新一郎、細川淳一、山形美絵子、池田啓、廣瀬晃一、中島裕史
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      20111110-12
  • [Presentation] 膠原病ならびにリウマチ性疾患患者のQuality of Life調査2011

    • Author(s)
      池田啓、川島広稔、高橋健太郎、平松有希子、横田雅也、岩田有史、柏熊大輔、若新英史、高取宏昌、須藤明、加々美新一郎、鈴木浩太郎、廣瀬晃一、渡辺紀彦、中島裕史
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20110717-20
  • [Book] Interleukin-25. Cytokine Frontiers (Regulation of immune responses in health and disease) (Ed Yoshimoto T)2013

    • Author(s)
      Nakajima H, Tamachi T, Hirose K
    • Total Pages
      247-266
    • Publisher
      Springer
  • [Remarks] 千葉大学大学院医学研究院 アレルギー・臨床免疫学

    • URL

      http://www.m.chiba-u.ac.jp/class/allergy/index.html

URL: 

Published: 2015-07-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi