2013 Fiscal Year Final Research Report
The roles of SOCS in obstructive pulmonary diseases
| Project/Area Number |
23591121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOICHIRO Matsumoto 九州大学, 九州大学病院, 講師 (60325462)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRAI Hiroko 九州大学, 大学院医学研究院呼吸器内科学, 大学院生
YUKARI Tajiri 九州大学, 大学院医学研究院呼吸器内科学, 大学院生
NAOTAKA Noda 九州大学, 大学院医学研究院呼吸器内科学, 大学院生
YUKO Matsunaga 九州大学, 大学院医学研究院呼吸器内科学, 大学院生
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| Project Period (FY) |
2011 – 2013
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| Keywords | SOCS / 喘息 / COPD / エフェロサイトーシス |
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| Research Abstract |
Allergic airway inflammation and airway responsiveness to inhaled Ach were attenuated in airway epithelium specific SOCS3 knockout (SOCS3/CC10Cre) mice than in wild type mice.
Apoptotic cell phagocytosis by alveolar macrophage (AM) is called efferocytosis. Pre-treatment of alveolar macrophage (AMs) with cigarette smoke extract (CSE) or trichostatin A (TSA), an HDAC inhibitor, suppressed efferocytosis and CSE reduced HDAC activity. TSA inhibited the activity of Rac, a key mediator of efferocytosis. These TSA-induced impairments were restored by treatment of AMs with aminophylline, a potent activator of HDAC. TSA profoundly down-regulated the expression of CD9 on AMs. The expression of CD9 was partly down-regulated by the Rac inhibitor. Pretreatment with an anti-CD9 mAb or CD9 siRNA inhibited efferocytosis, which was attributable to the reduced binding of AMs to apoptotic cells. These results suggest that smoking impairs efferocytosis via inhibition of HDAC/Rac/CD9 pathways.
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Research Products
(5 results)
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[Journal Article] Cigarette smoke impairs phagocytosis of apoptotic neutrophils by alveolar macrophages via inhibition of the histone deacetylase/Rac/CD9 pathways2013
Author(s)
Noda N, Matsumoto K, Fukuyama S, Asai Y, Kitajima H, Seki N, Matsunaga Y, Kan-O K, Moriwaki A, Morimoto K, Inoue H, Nakanishi Y
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Journal Title
Int Immunol
Volume: 25(11)
Pages: 643-50
Peer Reviewed
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[Journal Article] A zinc chelator TPEN attenuates airway hyperresponsiveness and airway inflammation in mice in vivo2011
Author(s)
Fukuyama S, Matsunaga Y, Zhanghui W, Noda N, Asai Y, Moriwaki A, Matsumoto T, Nakano T, Matsumoto K, Nakanishi Y, Inoue H
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Journal Title
Allergol Int
Volume: 60(3)
Pages: 259-66
Peer Reviewed
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