2013 Fiscal Year Final Research Report
Establishment of the comprehensive medical treatment strategy of chronic obstructive pulmonary disease based on the concept of cardio-pulmonary connection
| Project/Area Number |
23591123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
KANAZAWA HIROSHI 大阪市立大学, 医学(系)研究科(研究院), 准教授 (90332957)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 閉塞性肺疾患 / 肺血管リモデリング / 左室拡張障害 / 肺過膨張 |
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| Research Abstract |
We comprehensively examined the physiologic lung function and right and left ventricular function in patients with chronic obstructive pulmonary disease (COPD), and established the rationale of the concept of cardio-pulmonary connection. Subsequently, we identified the selective biomarker which can be sensitively reflected this concept. Furthermore, we determined the candidate gene which specifies the dynamics of pulmonary circulation in patients with COPD. And the drug selection in consideration of the improvement of right and left ventricular function was introduced on medical treatment strategy based on the concept of heart-and-lung connection. We newly demonstrated the theory for realizing improvement in the exercise capacity resulting from the efficient oxygen transport ability to the peripheral muscles.
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