2013 Fiscal Year Final Research Report
Epidemiology in patients with COPD with depression and sleep disorder and systemic biomakers in depressed COPD patients in Japan
| Project/Area Number |
23591130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 慢性閉塞性肺疾患 / 喫煙 / うつ病 / 睡眠障害 / モノアミン / バイオマーカー |
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| Research Abstract |
The prevalence of depression and sleep disorder in patients with COPD was significantly higher than in the controls, and the relative risk of depression and sleep disorder in COPD was 7.6 and 1.8-folds, respectively. The COPD patients with depression had significantly more frequent exacerbations and hospitalizations than those without depression or sleep disorder.
The plasma 5-hydroxyindole acetic acid (5-HIAA), metabolite of serotonin, level in depressed COPD patients was significantly higher than in non-depressed COPD patients and non-smokers, but not smokers. The plasma 5-HIAA level was significantly associated with the severity of depression in patients with COPD.
The management for depression and sleep disorder is necessary in patients with COPD, and the measurement of plasma 5-HIAA levels may be helpful to detect the depression in patients with COPD.
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[Journal Article] Prognostic value of EGFR mutation and ERCC1 in patients with non-small cell lung cancer undergoing platinum-based chemotherapy2013
Author(s)
Yamashita F, Azuma K, Yoshida T, Yamada K, Kawahara A, Hattori S, Takeoka H, Zaizen Y, Kawayama T, Kage M, Hoshino T
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Journal Title
PLoS One
Volume: 8
Pages: e71356
Peer Reviewed
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[Journal Article] IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-132013
Author(s)
Sawada M, Kawayama T, Imaoka H, Sakazaki Y, Oda H, Takenaka S, Kaku Y, Azuma K, Tajiri M, Edakuni N, Okamoto M, Kato S, Hoshino T
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Journal Title
PLoS One
Volume: 8
Pages: e54623
Peer Reviewed
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[Journal Article] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics2012
Author(s)
Matsunaga K, Yanagisawa S, Hirano T, Ichikawa T, Koarai A, Akamatsu K, Sugiura H, Minakata Y, Matsunaga K, Kawayama T, Ichinose M
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Journal Title
Clin Exp Allergy
Volume: 42
Pages: 775-781
Peer Reviewed
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[Journal Article] Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias2011
Author(s)
Okamoto M, Hoshino T, Kitasato Y, Sakazaki Y, Kawayama T, Fujimoto K, Ohshima K, Shiraishi H, Uchida M, Ono J, Ohta S, Kato S, Izuhara K, Aizawa H
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Journal Title
Eur Respir J
Volume: 37
Pages: 1119-1127
Peer Reviewed
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[Journal Article] Overexpression of chitinase 3-like 1/ykl-40 in lung-specific il-18-transgenic mice, smokers and COPD2011
Author(s)
Sakazaki Y, Hoshino T, Takei S, Sawada M, Oda H, Takenaka S, Imaoka H, Matsunaga K, Ota T, Abe Y, Miki I, Fujimoto K, Kawayama T, Kato S, Aizawa H
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Journal Title
PLoS One
Volume: 6
Pages: e24177
Peer Reviewed
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[Presentation] Validation of deep inspiratory and expiratory plane chest radiography technique for detection of chronic obstructive pulmonary disease2013
Author(s)
Kinoshita T, Kawayama T, Sakazaki Y, Imamura Y, Ikedow Y, Hirai R, Matsunaga K, Shimada T, Hoshino T
Organizer
American Thoracic Society international conference
Place of Presentation
Philadelphia, PA, USA
Year and Date
2013-05-19
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[Presentation] M2 macrophage marker CD163 and CD204 expression on alveolar macrophages in the lungs of patients with COPD2013
Author(s)
Kaku Y, Imaoka H, Morimatsu Y, Sakazaki Y, Sawada M, Oda H, Takenaka S, Matsuoka M, Kawayama T, Hoshino T
Organizer
American Thoracic Society international conference
Place of Presentation
Philadelphia, PA, USA
Year and Date
2013-05-19
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[Presentation] Overexpression of chitinase-3-like 1/YKL-40 in lung-specific IL-18 transgenic mice, smokers and COPD2012
Author(s)
Kaku Y, Sakazaki Y, Imakoka H, Takei S, Sawada S, Oda H, Takenaka S, Matsunaga K, Kawayama T, Hoshino T
Organizer
American Thoracic Society international conference
Place of Presentation
San Francisco, CA, USA
Year and Date
2012-05-19
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[Presentation] Expression of IL-18 receptor i the lungs of chronic obstructive pulmonary disease (COPD)2011
Author(s)
Takenaka S, Hoshino T, Sakazaki Y, Sawada M, Oda H, Imaoka H, Takei S, Kinoshita T, Kawayama T, Aizawa H
Organizer
American Thoracic Society international conference
Place of Presentation
Denver, CO, USA
Year and Date
2011-05-16
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[Presentation] IL-18 and IL-18 receptor alpha expression in allergic asthma2011
Author(s)
Imaoka H, Hoshino T, Sakazaki Y, Sawada M, Oda H, Takenaka S, Kawayama T, Gauvreau G, O'Byrne PM, Aizawa H
Organizer
American Thoracic Society international conference
Place of Presentation
Denver, CO, USA
Year and Date
2011-05-16
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