2014 Fiscal Year Final Research Report
Diagnosing histologic subtype of lung cancer by microRNA analysis from bronchoscopic samples
| Project/Area Number |
23591131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Takashi 福島県立医科大学, 医学部, 准教授 (60322343)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 気管支鏡 / 肺癌 |
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| Outline of Final Research Achievements |
The purpose of this study was to evaluate the concordance of histologic types of lung cancer diagnosed with bronchial biopsy or cytology specimens by endobronchial ultrasonography with a guide sheath (EBUS-GS) and the final diagnosis of the resected specimen. From July 2003 to December 2011, 203 patients with primary lung cancer diagnosed by EBUS-GS subsequently underwent curative pulmonary resection. These 203 cases were retrospectively analyzed. Of the 40 cases diagnosed as Sq by EBUS-GS, 37 cases were diagnosed as Sq, and three cases were diagnosed as non-Sq following surgical resection. Of the 159 cases diagnosed as non-Sq by EBUS-GS, non-Sq was diagnosed in 151 cases, Sq was diagnosed in six cases, and small cell carcinoma (Sm) was diagnosed in two cases following surgical resection. In 48 cases (23.6%), immunohistochemical staining of EBUS-GS-TBB specimens was performed. TTF-1 staining was the most frequently performed (n=37, 18%).
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| Free Research Field |
呼吸器内科学
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