2014 Fiscal Year Final Research Report
Molecular biological influence of sleep apnea syndrome on circadian clock system
| Project/Area Number |
23591147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
CHIKUMI Hiroki 鳥取大学, 医学部付属病院, 教授 (90283994)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 睡眠時無呼吸症候群 / 時計遺伝子 / 概日時計 / 時計被制御遺伝子 |
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| Outline of Final Research Achievements |
Sleep apnea syndrome is one of the important diseases, which causes many physiological impacts to human. Obstructive sleep apnea causes the repeated apnea and hypopnea during sleep, which affects the circadian clock that is composed of clock genes and molecular biological mechanism. We found several clock-controlled genes with cis-elements of E-box, D-box or RRE (REV-ERBα/ROR response element). Further studies are needed to reveal the relationship between dysfunction of circadian clock and sleep apnea syndrome.
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| Free Research Field |
呼吸器内科学
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