Analysis of angiogenetic factor in interstitial pneumonia

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591164
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nippon Medical School
• Principal Investigator: KUNUGI Shinobu 日本医科大学, 医学部, 講師 (30350036)
• Co-Investigator(Kenkyū-buntansha): TERASAKI Yasuhiro 日本医科大学, 医学部, 准教授 (50332870)
• Co-Investigator(Renkei-kenkyūsha): NAGASAKA Shinya 日本医科大学, 医学部, 助教 (00573239) ; MIYAKE Kouichi 日本医科大学, 医学部, 准教授 (90267211) ; TAKAHASHI Mikiko 日本医科大学, 医学部, 助教 (40516077)
• Project Period (FY): 2011 – 2013
• Keywords: 間質性肺炎 / 肺胞上皮 / miRNA

Research Abstract

We have been investigated pathogenesis of early intra-alveolar fibrotic process in interstitial pneumonia. We showed fibroblast differentiation into myofibroblast and decreased neovasculization in intra-alveolar fibrotic lesion of idiopathic pulmonary fibrosis. However, there is only limited information concerning the role of miroRNA in lung fibrotic process. Forthermore, microRNA and exosomal microRNA in bronchoalveolar lavage in lung fibrotic process are not investigated. We investigate exosomal microRNA in brochoalveolar lavage flood in mouse model of bleomycin induced lug fibrosis.

Research Products

• [Journal Article] Immunoglobulin G4-related lung disease : clinicoradiological and pathological features (2013)
  • Author(s): Matsui S, Hebisawa A, Sakai F, Yamamoto H, Terasaki Y, Kurihara Y, Waseda Y, Kawamura T, Miyashita T, Inoue H, Hata N, Masubuchi H, Sugino K, Kishi J,Kobayashi H, Usui Y, Komazaki Y, Kawabata Y, Ogura T.
  • Journal Title: Respirology Volume: 18(3) Pages: 480-7
  • Peer Reviewed
• [Journal Article] Familial interstitial pneumonia in an adolescent boy with surfactant protein C gene (Y104H) (2013)
  • Author(s): Kuse N, Abe S, Hayashi H, Kamio K, Saito Y, Azuma A, Kudoh S, Kunugi S, Fukuda Y, Setoguchi Y, Gemma A.
  • Journal Title: Sarcoidosis Vasc Diffuse Lung Dis. Volume: 30(1) Pages: 73-7
  • Peer Reviewed
• [Journal Article] Role of survivin in acute lung injury : epithelial cells of mice and humans (2013)
  • Author(s): Terasaki Y, Terasaki M, Urushiyama H, Nagasaka S, Takahashi M, Kunugi S, Ishikawa A, Wakamatsu K, Kuwahara N, Miyake K, Fukuda Y.
  • Journal Title: Lab Invest Volume: 93(10) Pages: 1147-63
  • Peer Reviewed
• [Journal Article] The difference of neovascularization in early intra-alveolar fibrosis between nonspecific interstitial pneumonia and usual interstitial pneumonia (2013)
  • Author(s): Takahashi M, Kunugi S, Terasaki Y, Terasaki M, Urushiyama H, Kuwahara N, Wakamatsu K, Nakayama T, Fukuda Y.
  • Journal Title: Pathol Int. Volume: 63(5) Pages: 237-44
  • Peer Reviewed
• [Book] 間質性肺炎の基本と考え方:病理.,臨床画像 (2014)
  • Author(s): 功刀しのぶ、福田悠
  • Total Pages: 260-269
  • Publisher: メジカルビュー社