2013 Fiscal Year Final Research Report
Pathogenesis of interstitial pneumonia caused by abnormal transport of lung surfactant
| Project/Area Number |
23591165
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IGUCHI Masaharu 金沢医科大学, 医学部, 助教 (60350758)
KOBAYASHI Makoto 金沢医科大学, 医学部, 助教 (20460355)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 間質性肺炎 / 肺サーファクタント / 細胞内輸送 / 肺胞上皮細胞 / ヘルマンスキー・パドラック症候群 / Ｒａｂ３８低分子量Ｇタンパク質 |
|---|
| Research Abstract |
To investigate pathogenesis of interstitial pneumonia that is caused by perturbation of lung surfactant transport, we analyzed the lungs of Long Evans Cinnamon rats, an animal model of Hermansky-Pudlak syndrome. There were remarkably enlarged giant lamellar bodies and increased lung surfactant in alveolar type II cells. Basal secretion of surfactant from the cells was inhibited but agonist-induced secretion was reversely enhanced. Adenovector-mediated delivery of Rab38 ameliorated these surfactant abnormalities. Unexpectedly, the rat lungs showed emphysematous changes. It is suspected that complication with infection, air pollution, and/or aging would be necessary in addition to a primary genetic abnormality to develop interstitial pneumonia in the disease.
|
-
[Journal Article] A three-microphone acoustic reflection technique using transmitted acoustic waves in the airway2013
Author(s)
Fujimoto Y, Huang J, Fukunaga T, Kato R, Higashino M, Shinomiya S, Kitadate S, Takahara Y, Yamaya A, Saito M, Kobayashi M, Kojima K, Oikawa T, Nakagawa K, Tsuchihara K, Iguchi M, Takahashi M, Mizuno S, Osanai K, Toga H.
-
Journal Title
J Appl Physiol
Volume: 115
Pages: 1119-1125
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
