Artifical kidney established by human kidney derived iPS cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591183
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: HISHIKAWA Keiichi 東京大学, 医学部附属病院, 准教授 (50255460)
• Co-Investigator(Renkei-kenkyūsha): FUJITA Toshiro 東京大学, 先端研, 特任教授 (10114125) ; NAKAUCHI Hiromitsu 東京大学, 医科学研究所, 教授 (40175485) ; ABURATANI Hiroyuki 東京大学, 先端研, 教授 (10202657)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 幹細胞 / iPS cells / メチル化

Outline of Final Research Achievements

In this study, we firstly identified key genes that determine memory of kidney derived iPS cells. By using these genes, we induced kidney cells efficiently from iPS cells. Finally, we tried to establish artificial kidney that was reported by Lanza et al. However, we could not reproduce the device by using human kidney derived iPS cells.

Free Research Field

再生医学