2013 Fiscal Year Final Research Report
Role of the synapse like vesicle in maintaining the podocyte function
| Project/Area Number |
23591186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWACHI Hiroshi 新潟大学, 医歯学系, 教授 (60242400)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 糸球体上皮細胞 / 蛋白尿 / スリット膜 / シナプス小胞 / SV2B |
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| Research Abstract |
We have previously found that SV2B is one of the critical molecules in maintaining the podocyte function. The study with several experimental models revealed that SV2B could be an early sensitive marker to detect podocyte injury. This study also revealed that the podocyte injury caused by the stimulation to the extracellular site of nephrin was p38MAPK dependent, and that p38MAPK inhibitor ameliorated proteinuria in this podocyte injury. We observed that p38MAPK inhibitor prevented the decrease in the expression of slit diaphragm molecules, nephrin and podocin, which is detect at the early phase of this podocyte injury. Besides, in this project we established the novel assay system to semi-quantitatively analyze the effect of reagents to glomerular permeability barrier with isolated glomeruli.
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[Journal Article] Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium2012
Author(s)
Yamaguchi H, Suzuki K, Nagata M, Kawase T, Sukumaran V, Thandavarayan RA, Kawauchi Y, Yokoyama J, Tomita M, Kawachi H, Watanabe K, Yoneyama H, Asakura H, Takagi R
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Journal Title
Med Mol Morphol
Volume: 45
Pages: 140-151
Peer Reviewed
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[Journal Article] Neurexin-1, a presynatic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys2011
Author(s)
Saito A, Miyauchi N, Hashimoto T, Karasawa T, Han GD, Kayaba M, Sumi T, Tomita M, Ikezumi Y, Suzuki K, Koitabashi Y, Shimizu F, Kawachi H
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Journal Title
Am J Physiol Regulatory Integrative Comparative Physiology
Volume: 300
Pages: R340-R348
DOI
Peer Reviewed
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