2013 Fiscal Year Final Research Report
Role of humoral factors in the development and progression of metabolic syndrome-related kidney diseases
| Project/Area Number |
23591191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
MUKOYAMA Masashi 京都大学, 医学(系)研究科(研究院), 准教授 (40270558)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Kiyoshi 京都大学, 医学研究科, 特定准教授 (60343232)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 腎臓学 / 内分泌学 / メタボリック症候群 |
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| Research Abstract |
Metabolic syndrome (MetS) represents impaired regulation of humoral or endocrine factors, such as the enhanced renin-angiotensin-aldosterone system. We investigated roles of humoral factors in MetS-associated renal injury.
The natriuretic peptide (ANP and BNP) receptor GC-A is abundantly expressed in renal tubules, but its role in glomerular injury is unknown. When GC-A knockout mice were subjected to aldosterone and high salt, massive proteinuria with marked podocyte injury was observed, which was alleviated with an ARB, antioxidant, or p38 MAPK inhibitor, suggesting their therapeutic potential.
In mouse models of diabetes with dyslipidemia, we found that TLR4 and its ligand MRP8, factors associated with homeostatic inflammation, were markedly upregulated together with worsening of nephropathy. Renal injury was significantly alleviated in TLR4-deficient mice. Expression of MRP8 was also enhanced in advanced human diabetic nephropathy, suggesting its role as a prognostic marker.
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[Journal Article] Predictive significance of kidney myeloid- related protein 8 expression in patients with obesity- or type 2 diabetes-associated kidney diseases2014
Author(s)
Kuwabara T, Mori K, Kasahara M, Yokoi H, Imamaki H, Ishii A, Koga K, Sugawara A, Yasuno S, Ueshima K, Morikawa T, Konishi Y, Imanishi M, Nishiyama A, Nakao K, Mukoyama M
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Journal Title
PLoS One
Volume: 9
Pages: e88942
DOI
Peer Reviewed
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[Journal Article] Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection2014
Author(s)
Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T
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Journal Title
PLoS One
Volume: 9
Pages: e87667
DOI
Peer Reviewed
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[Journal Article] Peritoneal fibrosis and high transport are induced in mildly pre-injured peritoneum by 3,4-dideoxyglucosone-3-ene in mice2013
Author(s)
Yokoi H, Kasahara M, Mori K, Yamada R, Namoto S, Yamamoto T, Seki N, Souma N, Yamaguchi T, Sugawara A, Mukoyama M, Nakao K
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Journal Title
Perit Dial Int
Volume: 33
Pages: 143-154
DOI
Peer Reviewed
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[Journal Article] Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice2012
Author(s)
Kuwabara T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Saito Y, Ogawa Y, Imamaki H, Kawanishi T, Ishii A, Koga K, Mori KP, Kato Y, Sugawara A, Nakao K
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Journal Title
Diabetologia
Volume: 55
Pages: 2256-2266
DOI
Peer Reviewed
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[Journal Article] Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury2012
Author(s)
Ogawa Y, Mukoyama M, Yokoi H, Kasahara M, Mori K, Kato Y, Kuwabara T, Imamaki H, Kawanishi T, Koga K, Ishii A, Tokudome T, Kishimoto I, Sugawara A, Nakao K
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Journal Title
J Am Soc Nephrol
Volume: 23
Pages: 1198-1209
DOI
Peer Reviewed
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[Journal Article] Pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal fibrosis2012
Author(s)
Yokoi H, Kasahara M, Mori K, Ogawa Y, Kuwabara T, Imamaki H, Kawanishi T, Koga K, Ishii A, Kato Y, Mori KP, Toda N, Ohno S, Muramatsu H, Muramatsu T, Sugawara A, Mukoyama M, Nakao K
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Journal Title
Kidney Int
Volume: 81
Pages: 160-169
DOI
Peer Reviewed
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[Journal Article] Therapeutic impact of leptin on diabetes, diabetic complications, and longevity in insulin-deficient diabetic mice2011
Author(s)
Naito M, Fujikura J, Ebihara K, Miyanaga F, Yokoi H, Kusakabe T, Yamamoto Y, Son C, Mukoyama M, Hosoda K, Nakao K
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Journal Title
Diabetes
Volume: 60
Pages: 2265-2273
DOI
Peer Reviewed
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[Journal Article] Japanese-Western Consensus Meeting on Biomarkers : Executive summary2011
Author(s)
Maisel AS, Nakao K, Ponikowski P, Peacock WF, Yoshimura M, Suzuki T, Tsutamoto T, Filippatos GS, Saito Y, Seino Y, Minamino N, Hirata Y, Mukoyama M, Nishikimi T, Nagai R
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Journal Title
Int Heart J
Volume: 52
Pages: 253-265
DOI
Peer Reviewed
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