2013 Fiscal Year Final Research Report
Analysis on the renoprotective effects and clinical significance of endogenous Vasohibin family in chronic kidney disease
| Project/Area Number |
23591193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Okayama University |
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Principal Investigator |
MAESHIMA YOHEI 岡山大学, 医歯(薬)学総合研究科, 教授 (10343287)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Yasufumi 東北大学, 加齢医学研究所腫瘍循環分野, 教授 (50178779)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 慢性腎臓病 / 血管新生 / 糖尿病性腎症 / Vasohibin-1 / 尿細管間質障害 |
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| Research Abstract |
The population of CKD patients in Japan is estimated as 13.3 million people. CKD is a risk factor of end-stage renal disease and cardiovascular disorders. Here, we examined the functional role of Vasohibin-1, a negative feedback regulator of angiogenesis, in CKD. Diabetic nephropathy, tubulointerstitial injuries induced by unilateral ureteral obstruction and acute kidney injury were exacerbated in the Vasofibin-1+/-- mice compared with the wild-type mice. Renal Vasohibin-1 expression was associated with crescentic lesions and interstitial inflammation in CKD patients. Elevated plasma/urinary levels of Vasohibin-1 predicted progressive renal functional deterioration in CKD patients. These results suggest the potential renoprotective effects of Vasohibin-1 and its potential as a novel biomarker in CKD.
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[Journal Article] Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein2013
Author(s)
Matsuda M, Tamura K, Wakui H, Maeda A, Ohsawa M, Kanaoka T, Azushima K, Uneda K, Haku S, Tsurumi-Ikeya Y, Toya Y, Maeshima Y, Yamashita A, Umemura S
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Journal Title
J. Biol. Chem.
Volume: 288巻
Pages: 19238-19249
DOI
Peer Reviewed
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[Journal Article] Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy2012
Author(s)
Tanabe K, Tamura Y, Lanaspa MA, Miyazaki M, Suzuki N, Sato W, Maeshima Y, Schreiner GF, Villarreal FJ, Johnson RJ, Nakagawa T
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Journal Title
Am J Physiol-Renal Physiol
Volume: 303巻
Pages: F1264-1274
DOI
Peer Reviewed
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[Journal Article] A sustained-release prostacyclin analog ONO-1301 ameliorates tubulointerstitial alterations in a mouse obstructive nephropathy model2012
Author(s)
Nasu T, Kinomura M, Tanabe K, Yamasaki H, Htay SL, Saito D, Hinamoto N, Watatani H, Ujike H, Suzuki Y, Sugaya T, Sugiyama H, Sakai Y, Matsumoto K, Maeshima Y, Makino H
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Journal Title
Am J Physiol-Renal Physiol
Volume: 302巻
Pages: F1616-1629
DOI
Peer Reviewed
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[Journal Article] Renal distribution of Vasohibin-1 in patients with chronic kidney disease
Author(s)
Hinamoto N, Maeshima Y, Saito D, Yamasaki H, Tanabe K, Nasu T, Watatani H, Ujike H, Kinomura M, Sugiyama H, Sonoda H, Kanomata N, Sato Y, Makino H
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Journal Title
Acta Medica Okayama
Volume: (In press)
Peer Reviewed
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