2013 Fiscal Year Final Research Report
Pathological involvement of carbonyl stress for development of cognitive impairment in CKD
| Project/Area Number |
23591196
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ASAHI Koichi 福島県立医科大学, 医学部, 准教授 (60274966)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 慢性腎臓病 / 認知機能 / 尿毒素 / メチルグリオキサール |
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| Research Abstract |
Recent clinical studies have demonstrated the close associations of cognitive impairment (CI) with plasma methylglyoxal (MG) levels and presence of kidney dysfunction. Tthe present study aims to examine whether MG is a direct causative substance for CI development. Experimental rats were divided into two groups: control and MG group (0.5% MG in drinking water), and fed a normal diet for 12 months. Cognitive function was evaluated by two behavioral tests. Serum MG was significantly elevated in the MG group at the end of study. The groups did not differ in cognitive function during the course of study. No time-course differences were found in oxidative stress markers between the two groups, while, antioxidants were significantly increased in the MG group. Long-term MG administration to rats with normal kidney did not cause CI, possibley due to a counter-balanced activation of the anti-oxidant system. Pathogenetic significance of MG for CI requires further investigation.
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[Presentation] Methylglyoxal (MG) and cerebro-renal interaction : Does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?2014
Author(s)
Kimio Watanabe, Kana Okada, Ryoji Fukabori, Yoshimitsu Hayashi, Koichi Asahi, Hiroyuki Terawaki, Kazuto Kobayashi, Tsuyoshi Watanabe, and Masaaki Nakayama
Organizer
8th International Congress on Uremia Research and Toxicity
Place of Presentation
(1 Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, School of Medicine, Fukushima Medical University Graduate School of Integrated Arts and Sciences, Hiroshima University Department of Molecular Genetics, Institute of Bio
Year and Date
2014-03-13
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