2013 Fiscal Year Final Research Report
Analysis of mechanism of cell polarity in NPHP polycystic kidney
| Project/Area Number |
23591197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka Medical College (2013)
Kyoto Prefectural University of Medicine (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 一次繊毛 / 嚢胞腎 / 急性腎障害 |
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| Research Abstract |
We expected that he random oriented cell division is an initial event for renal tubule expansion and precedes cell proliferation in inv mutant kidneys. Then, we analyzed the localization of the cell polarity factor of the renal tubular epithelial cells of a cystic kidney. In our analysis, the difference of intracellular localization of the cell polarity factor was not observed in cystic and normal kidney. These results suggested that the cause of a cystic kidney was not disorder of cell polarity.
Next, for the analysis of the cilia function in the renal tubular cells of a proliferation stage, we produced the acute kidney injury model which tubular cells caused cell proliferation and apoptosis simultaneously by ischemia-reperfusionmethod.
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