2013 Fiscal Year Final Research Report
Treating strategie for CKD with Klotho as a targetting molecule
| Project/Area Number |
23591204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TSUCHIYA KEN 東京女子医科大学, 医学部, 准教授 (00246472)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUCHIYA Mariko 東京女子医科大学, 医学部, 准教授 (00266826)
SHIOHIRA Shunji 東京女子医科大学, 医学部, 助教 (00529232)
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| Project Period (FY) |
2011 – 2013
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| Keywords | CKD / klotho / リン / 繊維化 |
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| Research Abstract |
Defects in Klotho gene expression in mice result in a syndrome resembling human aging that resembling with pathophysiology of chronic kidney disease (CKD). It has been clarified that membrane Klotho functions as a co-receptor for fibroblast growth factor 23 (FGF23) that regulate phosphate metabolism. Renal expression of the Klotho gene is markedly suppressed in CKD. Since renal fibrosis is a major risk factor for progression of CKD, renal interstitial fibrosis and Klotho expression should be correlated with each other. In this project, we explored the role and biological properties of Klotho, and especially focused on the phosphate metabolism, anti-fibrotic mechanism and clinical relevance of Klotho by measuring serum Klotho level in CKD. A reduction of Klotho expression aggravates renal interstitial fibrosis and that fibrosis-related factors regulate Klotho expression, making a vicious spiral in CKD. Thus, Klotho molecule is a targeting molecule in therapeutic strategy in CKD.
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