2013 Fiscal Year Final Research Report
Analysis of paracellular sodium ion transport in the thin ascending limb of Henle's loop
| Project/Area Number |
23591211
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Yoshiaki 日本大学, 医学部, 教授 (00221250)
UCHIDA Shinichi 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (50262184)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 細いヘンレの上行脚 / 細胞間隙 / ナトリウムイオン輸送 |
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| Research Abstract |
We analyzed paracellular sodium ion transport mechanism in the thin ascending limb, which plays an important role in mammalian urine-concentrating mechanism, using in vitro microperfusion technique. We examined whether aldosterone and insulin affected the transepithelial voltages or not. However, the transepithelial voltages remained unchanged. These results meant that both of them did not affect a sodium ion transport in this segment. Besides, according to just a few experiments, insulin like growth factor - 1 also suggested the same result.
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