Development of artificial kidney for removal of anionic uremic toxins

2015 Fiscal Year Final Research Report

• Project/Area Number: 23591212
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nippon Medical School (2012-2015); University of Tsukuba (2011)
• Principal Investigator: TSURUOKA Shuichi 日本医科大学, 医学(系)研究科(研究院), 教授 (50285798)
• Co-Investigator(Kenkyū-buntansha): YAMAGATA Kunihiro 筑波大学, 医療医学系, 教授 (90312850)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Keywords: 尿毒症性物質 / インドキシル硫酸 / バイオ人工腎臓 / 尿細管輸送

Outline of Final Research Achievements

We found that anionic uremic toxins such as indoxyl sulfate, p-cresyl sulphate, and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid stimulated proliferation of cultured smooth vascular cells via phosphorylation of proteins related to cell signaling (such as MAP kinase). We also established cultured renal tubular cells with high transport rate of these toxins. We further established the systems of artificial kidney with high capacity to remove these toxins.

Free Research Field

腎臓内科学