2013 Fiscal Year Final Research Report
Renal renin-angiotensin system and tubular prorenin endocytosis in diabetic nephropathy with microalbuminuria
| Project/Area Number |
23591214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TOJO Akihiro 東京大学, 医学部附属病院, 講師 (50292917)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 糖尿病性腎症 / レニン・アンジオテンシン系 / アルブミン / プロレニン |
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| Research Abstract |
Glomerular filtration of prorenin and angiotensinogen were increased as similar to that of albumin in early stage diabetic nephropathy with microalbuminuria, and the increased tubular reabsorption of prorenin and angiotensinogen contributed to the enhanced renal renin-angiotensin system in diabetic nephropathy. Suppression of tubular reabsorption of prorenin can be a new target to prevent progression of diabetic nephropathy.
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