2013 Fiscal Year Final Research Report
The systemic NAD world in chronic kidney disease
| Project/Area Number |
23591218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TATSUMI Sawako 徳島大学, ヘルスバイオサイエンス研究部, 助教 (80420545)
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| Co-Investigator(Kenkyū-buntansha) |
KIDO Shinsuke 徳島大学, 大学院ヘルスバイオサイエンス研究部, 特任助教 (30437652)
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| Project Period (FY) |
2011 – 2013
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| Keywords | リン / ニコチンアミド / NAD / 慢性腎臓病 |
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| Research Abstract |
This study determines the presence of the new phosphate(Pi)metabolic pathway through the nicotinamide phosphoribosyltransferase(Nampt)as the first rate-limiting enzyme in converting NAM to NAD.The activation of Nampt caused the significantly increased levels of urinary Pi excretion and the decreased levels of intestinal Pi absorption.The present data suggest that the cause of hypophosphatemia and hyperphosphaturia observed after 70% hepatectomy is caused by abnormal Nampt/NAM activation in the liver and kidney.
These result shows presence of the liver-kidney axsis in Pi metabolism.
We examine a mechanism to do constantly the Pi/Ca ratio through Nampt.We think these research may be contribute to the prevention of cardiovascular disease development of patients with chronic renal disease.
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[Journal Article] Molecular Mechanisms of Cadmium-Induced Fibroblast growth Factor 23 Upregulation in Osteoblast-Like Cells2014
Author(s)
Kido S, Fujihara M, Nomura K, Sasaki S, Mukai R, Ohnishi R, Kaneko I, Segawa H, Tatsumi S, Izumi H, Kohno K, Miyamoto KI
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Journal Title
Toxicol Sci
Volume: 139(2)
Pages: 301-316
DOI
Peer Reviewed
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[Journal Article] Hepatectomy-Related Hypophosphatemia : A Novel Phosphaturic Factor in the Liver-Kidney Axis2014
Author(s)
Nomura K, Tatsumi S, Miyagawa A, Shiozaki Y, Sasaki S, Kaneko I, Ito M, Kido S, Segawa H, Sano M, Fukuwatari T, Shibata K, Miyamoto KI
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Journal Title
J Am Soc Nephrol
Volume: vol.25, No.4
Pages: 761-772
DOI
Peer Reviewed
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[Journal Article] Effect of dietary components on renal inorganic phosphate (Pi) excretion induced by a Pi-depleted diet2014
Author(s)
Ohnishi R, Segawa H, Ohmoto T, Sasaki S, Hanazaki A, Mori A, Ikuta K, Furutani J, Kawakami E, Tatsumi S, Hamada Y, Miyamoto K
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Journal Title
J Med Invest
Volume: 61(1.2)
Pages: 162-170
URL
Peer Reviewed
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[Journal Article] Identification and functional analysis of a splice variant of mouse sodium-dependent phosphate transporter Npt2c2012
Author(s)
Kuwahara S, Aranami F, Segawa H, Onitsuka A, Honda N, Tominaga R, Hanabusa E, Kaneko I, Yamanaka S, Sassaki S, Ohi A, Nomura K, Tatsumi S, Kido S, Ito M, Miyamoto K
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Journal Title
J Med Invest
Volume: 59(1.2)
Pages: 116-126
URL
Peer Reviewed
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[Journal Article] Processing and stability of type IIc sodium-dependent phosphatre cotransporter mutations in patients with hereditary hypophosphatemia rickets with hypercalciuria2012
Author(s)
Haito-Sugino S, Ito M, Ohi A, Shiozaki Y, Kangawa N, Nishiyama T, Aranami F, Sasaki S, Mori A, Kido S, Tatsumi S, Segawa H, Miyamoto K
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Journal Title
Am J Physiol Cell Physiol
Volume: 302
Pages: C1316-1330
DOI
Peer Reviewed
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[Journal Article] Sodium-dependent phosphate cotransporters : Lessons from gene knockout and mutation studies2011
Author(s)
Miyamoto K, Haito-Sugino S, Kuwahara S, Ohi A, Nomura K, Ito M, Kuwahata M, Kido S, Tatsumi S, Kaneko I, Segawa H
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Journal Title
J Pharm Sci
Volume: 100(9)
Pages: 3719-3730
DOI
Peer Reviewed
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[Journal Article] Inorganic phosphate homeostasis in sodium-dependent phosphate co-transporter Npt2b+/- mice2011
Author(s)
Ohi A, Hanabusa E, Ueda O, Segawa H, Horiba N, Kaneko I, Kuwahara S, Mukai T, Sasaki S, Tominaga R, Furutani J, Aranami F, Ohtomo S, OikawaY, Kawase Y, Wada NA, Tachibe T, Kakefuda M, Tateishi H, Matsumoto K, Tatsumi S, Kido S, Fukushima N, Jishage KI, Miyamoto K
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Journal Title
Am J Physiol Renal Physiol November
Volume: 301
Pages: F1105- F1113
DOI
Peer Reviewed
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[Presentation] 骨とリン利尿因子2013
Author(s)
辰巳佐和子,木戸慎介,瀬川博子,宮本賢一
Organizer
第58回日本透析医学会学術集会・総会
Place of Presentation
福岡国際会議場(福岡県)
Year and Date
2013-06-21
Invited
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[Presentation] Mechanisms of hyperphosphatemia in the osteocyte-abelated mice2012
Author(s)
Tatsumi S, Kamatani T, Nomura K, Yoshimi A, Shiozaki Y, Sasaki S, Manabe M, Kido S, Segawa H, Miyamoto K
Organizer
Americal Society of Nephrology
Place of Presentation
San Diego Convention Center, CA,USA
Year and Date
2012-11-02
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[Presentation] Role of Sodium-Dependent Phosphate(Pi)Transporter(Npt2b)on Salivary Pi Secretion2011
Author(s)
Segawa H, Mukai T, Ohnishi S, Sasaki S, Ohi A, Kuwahara S, Kido S, Tatsumi S, Ishikawa Y, Ueda O, Horiba N, Jishage K, Fukushima N, Miyamoto K
Organizer
Americal Society of Nephrology
Place of Presentation
Pennsylvania Convention Center in Philadelphia,USA
Year and Date
2011-11-11
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[Presentation] Molecular Consequences of the SLC34A3 Mutations of Hereditary Hypophosphatemic Rickets with Hypercalciuria(HHRH)2011
Author(s)
Ohi A, Haito Sugino S, Ito M, Shiozaki Y, Nomura K,Kusaka Y, Sasaki S, Ohnishi S, Yamaguchi S, Kido S, Tatsumi S,Segawa H, Miyamoto K
Organizer
Americal Society of Nephrology
Place of Presentation
Pennsylvania Convention Center in Philadelphia,USA
Year and Date
2011-11-10
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[Book] 日本消化吸収学会雑誌2012
Author(s)
桑原煩治,大井彰子,野村憲吾,辰巳佐和子,木戸慎介,瀬川博子,宮本賢一
Total Pages
11
Publisher
日本消化吸収学会(Vol.34 No.3)
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[Book] 循環器内科2012
Author(s)
辰巳佐和子,野村憲吾,釜谷達哉,宮本賢一
Total Pages
253-259(324P)
Publisher
科学評論社(Vol.71 No.3)
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