2013 Fiscal Year Final Research Report
Analyses of bone fragility factors focused on bone chemical composition in chronic kidney disease
| Project/Area Number |
23591223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Oita University of Nursing and Health Sciences |
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Principal Investigator |
IWASAKI YOSHIKO 大分県立看護科学大学, 看護学部, 助教 (10360059)
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| Co-Investigator(Kenkyū-buntansha) |
KAZAMA Junichiro 新潟大学, 医歯学総合病院, 准教授 (10345499)
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| Co-Investigator(Renkei-kenkyūsha) |
YANO Shozo 島根大学, 医学部, 准教授 (80403450)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 腎性骨症 / 骨脆弱性 / 骨組成変化 / ラマン分光法 / 骨折寄与因子 |
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| Research Abstract |
Patients with chronic kidney disease (CKD) including dialysis patients have high risk of bone fracture. In order to elucidate the mechanisms underlying bone fragility in CKD patients we analyzed the bone material properties which indicate chemical composition. The bone samples from CKD represented lower storage modulus, which is one of mechanical properties, accompanied with the changes of bone chemical composition. These changes were influence on bone mechanical properties independent of bone mineral density, bone turnover, and hormones regulating bone metabolism. In addition, changes of bone chemical composition were improved by preventing accumulated uremic toxins in sera. These results suggest that controls for uremic conditions are possible new therapeutic approach for bone fragility.
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