2013 Fiscal Year Final Research Report
Analysis of molecular functions of presenilin in CSF phosphorylation of tau
| Project/Area Number |
23591231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Gunma University |
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Principal Investigator |
IKEDA MASAKI 群馬大学, 医学部附属病院, 講師 (50222899)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Koichi 群馬大学, 大学院医学系研究科, 教授 (00124652)
YAMAZAKI Tsuneo 群馬大学, 大学院保健学研究科, 教授 (80200658)
FUJITA Yukio 群馬大学, 大学院医学系研究科, 講師 (70420172)
MAKIOKA Kouki 群馬大学, 医学部附属病院, 助教 (10420176)
FURUTA Natsumi 群馬大学, 医学部附属病院, 助教 (80625583)
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| Co-Investigator(Renkei-kenkyūsha) |
SHOJI Mikio 弘前大学, 大学院医学研究科 (60171021)
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| Project Period (FY) |
2011 – 2013
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| Keywords | プレセニリン / タウ / 脳脊髄液 / アルツハイマー病 / 遺伝子変異 |
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| Research Abstract |
We confirmed 6 AD different PS1 mutations (T99A, H131R, H163R, M233L, L219R, V272A) in 6 independent Japansese FAD families. They showed slight elevation of CSF ptau (199, 181), reduction of Ab1-42, Ab1-40 and Ab1-38. While CSF Ab1-42 remained same level, CSF Ab1-40 and Ab1-38 gradually decreased. This may suggest active sites of gamma-secretase are different between sporadic AD and PS1 mutatnt AD patients, and Ab processing might be changing in aging of PS1 mutant AD.
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Research Products
(28 results)
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[Presentation] PiB-PET所見などによりアルツハイマー病と考えられたposterior cortical atrophyの3症例2013
Author(s)
池田将樹,田代裕一,荒木邦彦,黒瀬佐知子,高井恵理子,普神直子,津田和寿,樋口徹也,岡本幸市,池田佳生,対馬義人
Organizer
第32回日本認知症学会学術集会
Place of Presentation
松本
Year and Date
2013-11-08
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[Presentation] Analysis of cognition, CSF and neuroimaging in cases of progressive aphasia2013
Author(s)
Ikeda M, Tashiro Y, Tsuda K, Takai E, Kurose S, Fugami N, Amari M, Harigaya Y, Yamazaki T, Yamaguchi H, Takatama M, Okamoto K, Higuchi T, Tsushima Y, Ikeda Y
Organizer
AAIC2013
Place of Presentation
米国、ボストン
Year and Date
2013-07-17
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[Presentation] Cerebral encephalopathy with cerebral amyloid angiopathy and numerous amyloid plaques presenting aberrant low levels of CSF Aβ1-40/1-422012
Author(s)
Ikeda M, Hirayanagi K, Arai M, Kakuda S, Makioka K, Furuta N, Kasahara H, Fujita Y, Amari M, Takatama M, Nakazato Y, Okamoto K
Organizer
AAIC2012
Place of Presentation
カナダ、バンクーバー
Year and Date
2012-07-15
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[Presentation] New evidence of temporal kinetics of CSF Aβ1-38/1-40/1-42 and phosphorylated tau in seven FAD cases with novel PSEN1 mutations2011
Author(s)
Ikeda M, Yonemura K, Kakuda S, Fujita Y, Hashimoto Y, Tashiro Y, Ishiguro K, Amari M, Takatama M, Harigaya Y, Okamoto K
Organizer
AAIC2011
Place of Presentation
フランス、パリ
Year and Date
2011-07-20
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