2013 Fiscal Year Final Research Report
Identification of novel anti-neural and anti-endothelial cell antibodies for diagnosis and therapy of autoimmune-mediated encephalitis
| Project/Area Number |
23591239
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Gifu University |
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Principal Investigator |
KIMURA Akio 岐阜大学, 医学(系)研究科(研究院), 准教授 (00362161)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Takeo 三重大学, 地域イノベーション学研究科, 教授 (00569197)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 抗神経抗体 / 自己免疫介在性脳炎 / 傍腫瘍性神経症候群 |
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| Research Abstract |
We identified novel anti-neural and anti-endothelial cell antibodies in serum and cerebrospinal fluid samples from patients with autoimmune-mediated encephalitis, who had no previous reported anti-neural and anti-endothelial cell antibodies. To identify these novel antibodies, we employed two-dimensional immunoblotting or immunoprecepitation using human neuroblastoma cells, human brain microvascular endothelial cells, or rat brain homogenate as the antigen source. As a result, we identified antibodies against intracellular adhesion molecule 5 in serum from a patient with Hashimoto encephalitis, ryanodine receptor 1 in serum from a patient with paraneoplastic cerebellar degeneration, and myosin regulatory light chain 12A in cerebrospinal fluid from a patient with paraneoplastic limbic encephalitis.
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[Presentation] Anti-endothelial cell antibodies in the Elderly with Extended White Matter Hyperintensity2011
Author(s)
Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Otaki H, Chousa M, Takemura M, Seishima M, Inuzuka T.
Organizer
The 63^<th> Annual Meeting of American Academy of Neurology
Place of Presentation
Honolulu
Year and Date
2011-04-13
