Macrophage function and polymorphism of PKCeta in neuromyelitis optica and multiple sclerosis

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591247
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyushu University
• Principal Investigator: MATSUSHITA Takuya 九州大学, 医学(系)研究科(研究院), 研究員 (00533001)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Satoshi 九州大学, 大学院医学研究院神経内科学, 共同研究員 (20596390)
• Project Period (FY): 2011 – 2013
• Keywords: 多発性硬化症 / 視神経脊髄炎 / マクロファージ / PRKCH

Research Abstract

Polymorphism of PKCeta (rs2230500) was not risk allele or disease modulation factor for multiple sclerosis (MS) or neuromyelitis optica (NMO). However, a ratio of CX3CR1 positive monocytes was increased in rs2230500-A positive group of MS without therapy than in the allele-negative group. From a measurement of cytokines/chemokines of CSF revealed that CXCL8 was increased in rs2230500- A positive group of MS at remission phase and primary progressive MS than in the allele-negative group. These findings suggest differences of function of macrophages or microglia between PKCeta polymorphisms.

Research Products

• [Journal Article] Protein kinase C‐ηpolymorphism rs2230500 does not confer disease susceptibility to multiple sclerosis or neuromyelitis optica (2013)
  • Author(s): Kawano Y, Matsushita T, Cui YW, Isobe N, Yoshimura S, Yonekawa T, Masaki K, Yamasaki R, Murai H, Kira J-I
  • Journal Title: Clin Exp Neuroimmunol Volume: 4(3) Pages: 283-7
• [Journal Article] Alterations in chemokine receptor expressions on peripheral blood monocytes in multiple sclerosis and neuromyelitis optica (2013)
  • Author(s): Cui YW, Kawano Y, Shi N, Masaki K, Isobe N, Yonekawa T, Matsushita T, Tateishi T, Yamasaki R, Murai H
  • Journal Title: Clin Exp Neuroimmunol Volume: 4(2) Pages: 201-5
• [Journal Article] Characteristic cerebrospinal fluid cytokine/chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosis (2013)
  • Author(s): Matsushita T, Tateishi T, Isobe N, Yonekawa T, Yamasaki R, Matsuse D, Murai H, Kira J-I
  • Journal Title: PLoS ONE Volume: 8(4) Pages: e61835
• [Presentation] Cytokine receptor expressions in monocyte subsets in multiple sclerosis, neuromyelitis optica, and amyotrophic lateral sclerosis (2013)
  • Author(s): Cui YW, Kawano Y, Shi N, Masaki K, Isobe N, Yonekawa T, Matsushita T, Tateishi T, Yamasaki R, Kira J
  • Organizer: PACTRIMS
  • Place of Presentation: Kyoto
  • Year and Date: 20131106-08
• [Presentation] Dysregulation of surface marker expressions on peripheral monocytes in multiple sclerosis (2012)
  • Author(s): Cui YW、Masaki K、Yamasaki R、Tateishi T、Matsushita T、Shi N、Ohyagi Y、Kira J
  • Organizer: PACTRIMS
  • Place of Presentation: Beijing
  • Year and Date: 20120913-15